Results 11 to 20 of about 1,494 (196)

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola [PDF]

Molecules, 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings, Neyaz M. D. Khan, Navdeep Kaur, Daniel Rodrigues, Christine Morrow, Aoife Boyd, Olivier P. Thomas   +6 more
doaj   +3 more sources

1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea [PDF]

Marine Drugs, 2015
The green alga Caulerpa cylindracea is a non-autochthonous and invasive species that is severely affecting the native communities in the Mediterranean Sea. Recent researches show that the native edible fish Diplodus sargus actively feeds on this alga and
Sandra A. De Pascali, Laura Del Coco, Serena Felline, Ernesto Mollo, Antonio Terlizzi, Francesco P. Fanizzi   +5 more
doaj   +4 more sources

Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment [PDF]

Journal of Biological Engineering
Nanofibrous scaffolds have been established as capable platforms for localized drug delivery systems of skin cancer management. Our study aimed to develop an electrospun nanofibrous scaffold loaded with indirubin, a naturally occurring bisindole alkaloid
Sajad Rahimi, Kamyar Khoshnevisan, Amir Hossein Izadi Nazar, Maryam Doostan, Hassan Maleki   +4 more
doaj   +2 more sources

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells [PDF]

Molecules
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw   +5 more
doaj   +2 more sources

Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence

Molecules, 2022
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa, Gereon A. Sommer, Thomas J. J. Müller   +2 more
doaj   +1 more source

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack [PDF]

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation.
Amelia, Puteri, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Kaneda, Toshio, Tougan, Takahiro, Horii, Toshihiro, Morita, Hiroshi   +6 more
openaire   +2 more sources

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source

Bisindole alkaloids from Voacanga grandifolia leaves

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, -, Yurika Ono, -, Eunji Jin, -, Yusuke Hirasawa, -, Toshio Kaneda, -, Abdul Rahman, -, Idha Kusumawati, -, Takahiro Tougan, -, Toshihiro Horii, -, Noor Cholies Zaini, -, Hiroshi Morita, -   +10 more
openaire   +3 more sources

An Alkaloid from a Highly Invasive Seaweed Increases the Voracity and Reproductive Output of a Model Fish Species

Marine Drugs, 2022
The invasive macroalga Caulerpa cylindracea has spread widely in the Mediterranean Sea, becoming a favorite food item for native fish for reasons yet unknown.
Valentina Schiano, Adele Cutignano, Daniela Maiello, Marianna Carbone, Maria Letizia Ciavatta, Gianluca Polese, Federica Fioretto, Chiara Attanasio, Antonio Palladino, Serena Felline, Antonio Terlizzi, Livia D’Angelo, Paolo de Girolamo, Mimmo Turano, Carla Lucini, Ernesto Mollo   +15 more
doaj   +1 more source

Enantioselective Strategies for The Synthesis of N−N Atropisomers

Angewandte Chemie, Volume 135, Issue 31, August 1, 2023., 2023
Recent advances in the enantioselective synthesis of N−N atropisomers are highlighted and discussed within this Review. In particular, the strategies and breakthroughs to obtain this novel and stimulating atropisomeric architecture are presented while a particular attention is given to mechanistic aspects.
Giovanni Centonze, Chiara Portolani, Paolo Righi, Giorgio Bencivenni   +3 more
wiley   +2 more sources