Results 41 to 50 of about 1,494 (196)

Circular dichroism calculation for natural products [PDF]

, 2013
Determination of the absolute configuration (AC) is often a challenging aspect in the structure elucidation of natural products. When chiral compounds possess appropriate chromophore(s), electronic circular dichroism (ECD) may provide a powerful approach
Alfarius Eko Nugroho, Hiroshi Morita
core   +1 more source

Antemitotic activity of strychnopentamine, a bisindolic alkaloid

Journal of Ethnopharmacology, 1984
Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.
Tits, Monique, Desaive, Claude, Marnette, J. M., Bassleer, Roger, Angenot, Luc   +4 more
openaire   +3 more sources

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]

, 2013
The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Albino, Astulla, Bargonetti, Betts, Bodnar, Boeira, Bradford, Burge, Burger, Cao, Clarke, Elmore, Farnebo, Funayama, Gewirtz, Glennon, Gollahon, Gorbunova, Greenberg, Gualberto, Hamsa, Holt, Im, Ji, Jones, Kim, Kim, Kusumoto, Kyo, Lansiaux, Levine, Liu, Meyerson, Moura, Möller, Nakamura, Noureini, Oh, Roberts, Rosenkranz, Sasaki, Shammas, Shammas, Shay, Shay, Shay, Song, Song, Sourkes, Tanaka, Tweedie, Wang, Wang, Wink, Wink, Wink, Wink, Wu, Xu, Zhao   +59 more
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Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum

Marine Drugs, 2013
In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum.
Magna Suzana Alexandre-Moreira, George Emmanuel C. de Miranda, Fabiana de Andrade Cavalcante, Jéssica Celestino Ferreira Sousa, Daysianne Pereira de Lira, Bárbara Viviana de Oliveira Santos, Bagnólia Araújo da Silva, Ana Carolina de Carvalho Correia, José Maria Barbosa-Filho, Luiz Henrique Agra Cavalcante-Silva   +9 more
doaj   +1 more source

Phenotype Screening of an Azole-bisindole Chemical Library Identifies URB1483 as a New Antileishmanial Agent Devoid of Toxicity on Human Cells [PDF]

, 2021
We report the evaluation of a small library of azole-bisindoles for their antileishmanial potential, in terms of efficacy on Leishmania infantum promastigotes and intracellular amastigotes. Nine compounds showed good activity on L.
Buffi G., De Santi M., Diotallevi A., Favi G., Galluzzi L., Lodola A., Lucarini S., Magnani M., Perez-Pertejo Y., Scalvini L., Verboni M.   +10 more
core   +4 more sources

Structure Elucidation and the Antimalarial Activity of Indole Alkaloids from Tabernaemontana macrocarpa Jack [PDF]

, 2021
星薬科大学博士（薬科学）doctoral ...
AMELIA, Puteri
core  

Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]

, 2022
Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko, Hildebrandt, Sarah, Keller, Judith, Manz, Christina, Mielke, Marion, Nick, Peter, Raorane, Manish L., Thieme, Marc   +7 more
core   +2 more sources

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of ?-Aryl-?-isocyanoacetate to Vinyl Phenyl Selenone

CHIMIA, 2014
Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj   +1 more source

Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling

Molecules, 2020
A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), iboxygaine (6), voacamine (7), voacorine (8) and conoduramine (9)—were ...
Smith B. Babiaka, Conrad V. Simoben, Kennedy O. Abuga, James A. Mbah, Rajshekhar Karpoormath, Dennis Ongarora, Hannington Mugo, Elvis Monya, Fidelis Cho-Ngwa, Wolfgang Sippl, Edric Joel Loveridge, Fidele Ntie-Kang   +11 more
doaj   +1 more source

Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites

Marine Drugs, 2017
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus
Amy E. Wright, K. Brian Killday, Debopam Chakrabarti, Esther A. Guzmán, Dedra Harmody, Peter J. McCarthy, Tara Pitts, Shirley A. Pomponi, John K. Reed, Bracken F. Roberts, Carolina Rodrigues Felix, Kyle H. Rohde   +11 more
doaj   +1 more source