Results 61 to 70 of about 1,494 (196)

Ligand‐Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide‐Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1

open access: yesBiochemistry Research International, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza   +6 more
wiley   +1 more source

Screening for Bioactive Compounds from Algae [PDF]

open access: yes, 2012
At present, functional foods are seen as a good alternative to maintain or even improve human health, mainly for the well-known correlation between diet and health.
Herrero, Miguel   +3 more
core   +2 more sources

Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity

open access: yesMalaria Journal, 2018
Background Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflammatory.
Isabela P. Ceravolo   +5 more
doaj   +1 more source

Antibacterial activities of selected edible plants extracts against multidrug-resistant Gram-negative bacteria [PDF]

open access: yes, 2013
BACKGROUND: In response to the propagation of bacteria resistant to many antibiotics also called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial.
Aimé G Fankam   +7 more
core   +1 more source

Arenaria serpyllifolia as a Natural Antiviolaceum Agent: Phytochemical, Biological, and Molecular Approaches

open access: yesChemistryOpen, Volume 14, Issue 11, November 2025.
Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı   +5 more
wiley   +1 more source

Plant-derived antimalarial agents: from crude extracts to isolated bioactive compounds [PDF]

open access: yes, 2011
Despite decades of intense research, malaria remains a deadly disease of the developing worlds. Drugresistance to limited available antimalarials, in part, has contributed to the persistence of this infectious disease.
Abdullah, Wan Omar, Ismail, Patimah
core  

Review: Marine natural products [PDF]

open access: yes, 2005
This review covers the literature published in 2003 for marine natural products, with 619 citations (413 for the period January to December 2003) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red ...
Blunt, John W.   +4 more
core   +3 more sources

Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors [PDF]

open access: yes, 2022
Introduction: The different and relevant roles of GSK-3 are of critical importance since they deal with development, metabolic homeostasis, cell polarity and fate, neuronal growth and differentiation as well as modulation of apoptotic potential.
Andrisano V.   +7 more
core   +1 more source

Indole alkaloids from marine sources as ootential leads againstinfectious diseases [PDF]

open access: yes, 2014
Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious
Araújo Júnior, João Xavier de   +10 more
core   +1 more source

Bisleuconothine A potentiates the effect of hyperbaric oxygen therapy against traumatic brain injury by enhancing P2X4 protein expressions [PDF]

open access: yes, 2020
Purpose: To investigate the effect of bisleuconothine A (BA), alone and in combination with hyperbaric oxygen (HO), on traumatic brain injury (TBI) in rats. Methods: Traumatic brain injury (TBI) was induced by dropping a 200-g weight of steel on the left
Fan, Danfeng   +8 more
core   +2 more sources

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