Results 31 to 40 of about 1,584 (196)

3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity [PDF]

, 2015
A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of the thiazole ring was substituted by a 7-azaindole moiety, was efficiently synthesized.
Attanzio, A., Barraja, P., Carbone, A., Ciancimino, C., Cirrincione, G., Di Vita, G., Diana, P., Livrea, M., Montalbano, A., Parrino, B., Span\uf2, V., Tesoriere, L.   +11 more
core   +2 more sources

Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]

PLoS ONE, 2014
The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma, Rajesh Ghangal, Raghvendra Sharma, Alok K Sinha, Mukesh Jain   +4 more
doaj   +1 more source

Antimicrobial activities of secondary metabolites of endophytic fungi isolated from Catharanthus roseus [PDF]

, 2017
Introduction: Recently, several endophytes have been shown to possess the potentials to synthesize novel bioactive compounds that have found use for drug discovery. We isolated endophytic fungi associated with Catharanthus roseus collected from the river
Abba, Chika C., Akpotu, Mark O., Esimone, Charles O., Eze, Peter M., Nwachukwu, Charles U., Okoye, Festus B. C., Umeokoli, Blessing O.   +6 more
core   +2 more sources

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of ?-Aryl-?-isocyanoacetate to Vinyl Phenyl Selenone

CHIMIA, 2014
Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj   +1 more source

Bisleuconothine A protects periodontal tissue via the regulation of RANKL expression and infiltration of inflammatory cells [PDF]

, 2020
Purpose: To investigate the protective effect of bisleuconothine A on periodontal tissue in rats and the mechanism involved. Methods: Adult male Sprague Dawley rats (n = 32) weighing 180 - 200 g (mean weight, 190 ± 10 g) were randomly assigned to four ...
Sun, Ping, Sun, Qiang, Wang, Fang
core   +2 more sources

Antemitotic activity of strychnopentamine, a bisindolic alkaloid

Journal of Ethnopharmacology, 1984
Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.
Tits, Monique, Desaive, Claude, Marnette, J. M., Bassleer, Roger, Angenot, Luc   +4 more
openaire   +3 more sources

Cell type matters : competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]

, 2023
Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko, Hildebrandt, Sarah Lea, Keller, Judith, L-Raorane, Manish, Manz, Christina, Mielke, Marion, Nick, Peter, Thieme, Marc   +7 more
core   +1 more source

Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b’]diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent

Molecules, 2019
Bisindolyl alkaloids represent a large family of natural and synthetic products that display various biological activities. Among the bisindole compounds, 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b:3,4-b’]diindoles have received little attention ...
Lei Peng, Xiaofei Zhang, Chunhao Yang
doaj   +1 more source

A Fluorinated Analogue of Marine Bisindole Alkaloid 2,2-Bis(6-bromo-1H-indol-3-yl)ethanamine as Potential Anti-Biofilm Agent and Antibiotic Adjuvant Against Staphylococcus aureus

Pharmaceuticals, 2020
Methicillin resistant Staphylococcus aureus (MRSA) infections represent a major global healthcare problem. Therapeutic options are often limited by the ability of MRSA strains to grow as biofilms on medical devices, where antibiotic persistence and ...
Raffaella Campana, Gianmarco Mangiaterra, Mattia Tiboni, Emanuela Frangipani, Francesca Biavasco, Simone Lucarini, Barbara Citterio   +6 more
doaj   +1 more source

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]

, 2013
The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Albino, Astulla, Bargonetti, Betts, Bodnar, Boeira, Bradford, Burge, Burger, Cao, Clarke, Elmore, Farnebo, Funayama, Gewirtz, Glennon, Gollahon, Gorbunova, Greenberg, Gualberto, Hamsa, Holt, Im, Ji, Jones, Kim, Kim, Kusumoto, Kyo, Lansiaux, Levine, Liu, Meyerson, Moura, Möller, Nakamura, Noureini, Oh, Roberts, Rosenkranz, Sasaki, Shammas, Shammas, Shay, Shay, Shay, Song, Song, Sourkes, Tanaka, Tweedie, Wang, Wang, Wink, Wink, Wink, Wink, Wu, Xu, Zhao   +59 more
core   +1 more source