Results 181 to 190 of about 1,443,667 (357)

Phase I clinical trial of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer [PDF]

, 2003
Roland Repp, Heidi H. van Ojik, Thomas Valerius, Gerard Groenewegen, GABRIELE WIELAND, C Oetzel, Bernhard Stockmeyer, W. Becker, Michael Eisenhut, H Steininger, Yashwant M. Deo, G.H. Blijham, J. R. Kalden, Jan G. J. van de Winkel, Martin Gramatzki   +14 more
openalex   +1 more source

Intradiabodies, Bispecific, Tetravalent Antibodies for the Simultaneous Functional Knockout of Two Cell Surface Receptors [PDF]

, 2003
Nina Jendreyko, Mikhail Popkov, Roger R. Beerli, Junho Chung, Dorian B. McGavern, Christoph Rader, Carlos F. Barbas   +6 more
openalex   +1 more source

Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives

VIEW, EarlyView.
In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu, Wenpeng Huang, Jingwei Zhou, Rachel J. Saladin, Youlan Lei, Weibo Cai, Lei Kang   +6 more
wiley   +1 more source

Targeting of saporin to CD25-positive normal and neoplastic lymphocytes by an anti-saporin/anti-CD25 bispecific monoclonal antibody: in vitro evaluation

, 1993
Pier Luigi Tazzari, S Zhang, Qia Chen, Sabrina Sforzini, Andrea Bolognesi, Fiorenzo Stirpe, Hong Xie, A. Moretta, Silvano Ferrini   +8 more
openalex   +2 more sources

T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites [PDF]

, 2003
Shigeto Yoshida, Tominari Kobayashi, Hiroyuki Matsuoka, Chisato Seki, William L. Gosnell, Sandra P. Chang, Akira Ishii   +6 more
openalex   +1 more source

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope

Acta Crystallographica Section D, EarlyView.
The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li, Ulla Mandel, Henk van Faassen, Matthew J. Parker, Max S. G. Legg, Greg Hussack, Henrik Clausen, Stephen V. Evans   +7 more
wiley   +1 more source

Large scale paired antibody language models [PDF]

arXiv
Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in ...
arxiv  

A recombinant bispecific single‐chain antibody induces targeted, supra‐agonistic CD28‐stimulation and tumor cell killing [PDF]

, 2003
Ludger Große‐Hovest, Ingo Hartlapp, Wolfgang Marwan, Gottfried Brem, Hans‐Georg Rammensee, Gundram Jung   +5 more
openalex   +1 more source

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

Journal of Biological Chemistry, 2021
J. Neijssen, R. Cardoso, Kristen M. Chevalier, L. Wiegman, T. Valerius, G. Anderson, Sheri L. Moores, J. Schuurman, P. Parren, W. Strohl, M. Chiu   +10 more
semanticscholar   +1 more source

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

Allergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy, Laura Vitale, Thomas O'Neill, Deena M. Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills‐Chen, Virginia Saley, Nicole M. Antczak, James M. Boyer, Kelly M. McManus, Noe Rico Montanari, Russell A. Hammond, Joel Goldstein, Lawrence J. Thomas, Tibor Keler, Diego Alvarado   +17 more
wiley   +1 more source