Results 91 to 100 of about 115,328 (341)

The Effects of Bone-Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX). [PDF]

Cancer Med
In this retrospective population study containing 139,859 patients, subjects receiving RANK‐ligand inhibitors had improved survival and decreased rates of skeletal‐related events relative to the overall cohort of patients with metastatic bone lesions.
Im BH, Zarrabi KK, Hochberg AR, Shah MS, Mark JR, Izes JK, Gomella PT, Lallas CD, Gomella LG, Metwalli AR.   +9 more
europepmc   +2 more sources

Bisphosphonate-induced periprosthetic fracture: a cause of painful total hip arthroplasty [PDF]

, 2014
Background. Cases have been reported in the literature of periprosthetic fractures associated with the use of bisphosphonates occurring in the long term following a Total Hip Replacement (THR).
Bhattacharyya, Rahul, O’Neill, Gavin, Periasamy, Kumar, Spence, Stephanie   +3 more
core   +4 more sources

Novel Radiolabeled Bisphosphonates for PET Diagnosis and Endoradiotherapy of Bone Metastases

Pharmaceuticals, 2017
Bone metastases, often a consequence of breast, prostate, and lung carcinomas, are characterized by an increased bone turnover, which can be visualized by positron emission tomography (PET), as well as single-photon emission computed tomography (SPECT ...
N. Pfannkuchen, M. Meckel, R. Bergmann, M. Bachmann, C. Bal, M. Sathekge, W. Mohnike, R. Baum, F. Rösch   +8 more
semanticscholar   +1 more source

OGFRL1 deficiency causes CRMO via pathological osteoclastogenesis, with therapeutic response to TNF inhibitor

Arthritis &Rheumatology, Accepted Article.
Objectives To verify the pathogenesis of the OGFRL1 loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a CRMO patient and investigate the underlying mechanism. Methods Whole exome sequencing and Sanger sequencing were performed to identify and confirm the variant.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis: a systematic review and meta-analysis

Frontiers in Endocrinology
Study DesignA systematic review and Meta-analysisObjectiveTo compare the efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis.Summary of Background DataWhile bisphosphonates have historically ...
Jia Yang, Xiaobo Guo, Zhongning Cui, Huikang Guo, Jia-Nan Dong   +4 more
doaj   +1 more source

Radiological Aspects of BRONJ after Dental Extractions in Ovariectomized Female Wistar Rats

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine, 2018
Experimental study in animal model - female Wistar rats – using two types of bisphosphonates (ibandronic acid and denosumab) for treating osteoporosis induced by ovariectomy, performing extractions in the maxillary central incisors and occurance of ...
Adela Cristina LAZĂR, Radu LĂCĂTUȘ, Robert PURDOIU, Lucia BEL, Orsolya SARPATAKI, Mariana PĂCURAR, Radu Septimiu CÂMPIAN   +6 more
doaj   +1 more source

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates

Drug Design, Development and Therapy, 2011
Maurizio Muratore, Eugenio Quarta, Antonella Grimaldi, Fabio Calcagnile, Laura Quarta Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy Abstract: Bisphosphonates have a long history in the treatment of osteoporosis and bone ...
Muratore M, Quarta E, Grimaldi A, Calcagnile F, Quarta L   +4 more
doaj  

Benefit of adjuvant bisphosphonates in early breast cancer treated with contemporary systemic therapy: A meta-analysis of randomized control trials

Heliyon
Background: The absolute and relative benefits of adjuvant bisphosphonates on disease-free survival and overall survival in patients receiving contemporary systemic therapy for early breast cancer is uncertain.
Abhenil Mittal, Faris Tamimi, Consolacion Molto, Massimo Di Iorio, Eitan Amir   +4 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source