Results 81 to 90 of about 52,862 (295)

Benefit of adjuvant bisphosphonates in early breast cancer treated with contemporary systemic therapy: A meta-analysis of randomized control trials

Heliyon
Background: The absolute and relative benefits of adjuvant bisphosphonates on disease-free survival and overall survival in patients receiving contemporary systemic therapy for early breast cancer is uncertain.
Abhenil Mittal, Faris Tamimi, Consolacion Molto, Massimo Di Iorio, Eitan Amir   +4 more
doaj   +1 more source

Modulation of Arachidonic Acid Metabolism by Pinoresinol Diglucoside Ameliorates Osteogenic Dysfunction via Coordinated NF‐κB Suppression and GSK3β/β‐Catenin Activation in Diabetic Osteoporosis

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its direct molecular targets and integrated mechanisms remain unclear.
Wenqi Jin, Yujing Tan, Lei Zhang, Weigeng She, Yunhang Chu, Xuenan Chen, Shuai Zhang, Liwei Sun   +7 more
wiley   +1 more source

Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management

, 2010
Luca Dalle Carbonare, Mirko Zanatta, Adriano Gasparetto, Maria Teresa ValentiClinic of Internal Medicine D, Department of Medicine, University of Verona, ItalyAbstract: Bisphosphonates (BPs) are widely used in the treatment of postmenopausal &shy ...
Mirko Zanatta, et al, Luca Dalle Carbonare, Adriano Gasparetto   +3 more
core  

Magnetothermal‐responsive drug release bone cement based on EGFR‐mutated lung cancer bone metastases

VIEW, EarlyView.
A novel magnetothermal‐responsive bone cement was developed by integrating PMMA/CPC/Osimertinib matrix with Fe3O4@SiO2@Zol nanomaterials. This dual‐drug system achieves controlled release, combining excellent mechanical properties with potent anti‐tumor activity and bone regulation for treating EGFR‐mutated LC‐BoM.
Kandi Xu, Kai Li, Hao Wang, Lishu Zhao, Xinyue Liu, Yujin Liu, Li Ye, Wengang Zhang, Zhimin Chen, Xuyang Chen, Yujie Li, Qianqian Zhang, Wencheng Zhao, Xuebin Zheng, Yu Chen, Yayi He   +15 more
wiley   +1 more source

Bisphosphonates

, 2013
Over the 40-year period during which bisphosphonates have been used in clinical practice, the mechanism of action for both simple and nitrogen-containing compounds has become clear, although sources variation in individual response still requires further
Bishop, NJ, Russell, Graham, Graham Russell, Nick J. Bishop   +3 more
core   +1 more source

Machine Learning‐Based Screening for Osteonecrosis of the Jaw in Panoramic Radiographs

Australian Dental Journal, EarlyView.
ABSTRACT Background Osteonecrosis of the jaw (ONJ) is a serious condition associated mainly with antiresorptive therapy and maxillofacial radiotherapy. As detection of its radiographic findings may facilitate patient referral, this study aimed to develop convolutional neural networks (CNNs) for ONJ screening in panoramic radiographs (OPGs).
Valéria Nagyová, Dominik Blaňár, Jan Kybic, Antonín Tichý   +3 more
wiley   +1 more source

Medication Related Osteonecrosis of the Jaw: Knowledge, Attitudes and Practice Patterns Among Australian Dental Practitioners

Australian Dental Journal, EarlyView.
ABSTRACT Background Medication related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive and antiangiogenic therapies. As the use of these medications continues to increase, dental practitioners play a critical role in prevention and management of at‐risk patients. This survey evaluated the awareness, knowledge
Ying Shi Chang, Christopher Friel, Gary Low, Albert Yaacoub, Stephen Clive Cox   +4 more
wiley   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

Bilateral Atypical Femoral Fractures in a Patient with Multiple Myeloma Treated with Intravenous Bisphosphonate Therapy

Case Reports in Orthopedics, 2014
Bisphosphonates are currently the standard approach to managing bone disease in multiple myeloma. Bisphosphonates have high bone affinity that inhibits osteoclastic activity and additionally reduces the growth factors released from malignant or ...
Ichiro Tonogai, Tomohiro Goto, Daisuke Hamada, Toshiyuki Iwame, Shinji Yoshioka, Takahiko Tsutsui, Yuichiro Goda, Hiroshi Egawa, Koichi Sairyo   +8 more
doaj   +1 more source

Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases

, 2008
Thomas J PolascikDivision of Urology, Department of Surgery, Duke University Medical Center, Durham, NC, USAAbstract: Bone metastases frequently occur in patients with advanced solid tumors, particularly breast and prostate cancers, and nearly all ...
Thomas J Polascik, Thomas Polascik
core   +1 more source