Results 61 to 70 of about 67,212 (289)

The survey of anti-inflammatory effect of bisphosphonates

Journal of Mazandaran University of Medical Sciences, 2009
(Received 13 Dec, 2008 ; Accepted 28 Jan, 2009)AbstractBisphosphonates are currently used in metabolic disorder of bone; however, there have been few studies that reviewed the role of anti-inflammatory and immune modulatory effect of this agent in in ...
Reza Shiari, Mohammad Mehdi Nasehi, Shervin Farivar, Bijan Hatamian   +3 more
doaj  

Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment [PDF]

, 2014
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and boneturnover markers after 1 year of treatment.
Brance, María Lorena, Brun, Lucas Ricardo Martín, Costanzo, Paulo R, Galich, Ana M., Grupo Argentino de Estudio del Ranelato de Estroncio, Larroudé, Maria S., Maffei, Laura, Moggia, Maria S., Premrou, Valeria, Rey, Paula, Salerni, Helena, Sarli, Marcelo A, Sánchez, Ariel, Vega, Eduardo   +13 more
core   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Coping with complexity: working beyond the guidelines for patients with multimorbidities [PDF]

, 2015
Primary care physicians believe they are delivering evidence-based care, understanding that adherence to evidence-based clinical guidelines results in tangible benefits in the populations for which they were developed.
Treadwell, Julian
core   +3 more sources

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Bone Healing After Tooth Extraction in a Patient on Oral Bisphosphonates: A Case Report

Osteology
Background: The present case report study aims to describe, from both clinical and histological aspects, the bone healing pattern in a patient under oral bisphosphonates therapy.
Antonello Falco, Lorenzo Vittorini Orgeas, Roberta Di Pietro, Loredana Masciotra, Sergio Rexhep Tari, Calogero Bugea, Antonio Scarano   +6 more
doaj   +1 more source

The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long-term use in post-menopausal osteoporosis

BMC Musculoskeletal Disorders, 2007
Background It is still unclear whether addition of calcium/vitamin D supplements leads to an incremental benefit in patients taking bisphosphonates and whether achievement of serum level of 25 (OH) vitamin D of at least 70 nmol/L has an impact on the ...
Fogelman Ignac, Constancio Leonor, Deane Andrew, Hampson Geeta   +3 more
doaj   +1 more source

Comparison of denosumab and oral bisphosphonates for the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis

BMC Musculoskeletal Disorders, 2022
Background Both denosumab and bisphosphonates have been demonstrated effective for glucocorticoid-induced osteoporosis. However, evidence-based medicine is still lacking to prove the clinical results between denosumab and bisphosphonates.
Lianghai Jiang, Jian Dong, Jianwei Wei, Lantao Liu   +3 more
doaj   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Bisphosphonates: An update

Journal of Pharmacy and Bioallied Sciences, 2012
Bisphosphonates are used widely for variety of bone condition, most notably IV bisphosphonates in the treatment of metastic bone lesion and oral bisphosphonates for osteoporosis.
Nalliappan Ganapathy, Subramanium Gokulnathan, Nataraj Balan, Thangadurai Maheswaran, Venkatesan   +4 more
doaj   +1 more source