Results 71 to 80 of about 36,968 (260)

Canal Cholesteatoma Presentation and Management: A Systematic Review and Meta‐Analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate current understanding of external auditory canal cholesteatoma (EACC), its symptomatic burden, clinical features, diagnostic approach, and management strategies to reduce delays in diagnosis. Data Sources PubMed, CINAHL, COCHRANE Library, and SCOPUS.
Angelica M. Walker, Matthew Cheung, Shaun A. Nguyen, Kate Bonham, Erin A. Harvey, Robert F. Labadie, Ted A. Meyer   +6 more
wiley   +1 more source

Bisphosphonates: Mechanisms of Action [PDF]

Endocrine Reviews, 1998
The geminal bisphosphonates are a class of drug, developed in the last 30 years, characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical effect on
openaire   +3 more sources

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Osteonecrose maxilar em pacientes portadores de doenças neoplásicas sob uso de bisfosfonatos Jaw osteonecrosis in patients with neoplastic diseases taking bisphosphonates

Revista Brasileira de Hematologia e Hemoterapia, 2008
A osteonecrose induzida por bisfosfonatos é uma complicação que pode ocorrer em pacientes acometidos por doença osteolítica tais como mieloma múltiplo, portadores de metástases tumorais em tecido ósseo, osteoporose e que fizeram uso de droga do grupo dos
Paulo S. S. Santos, Liane M. Gambirazi, Valtuir B. Felix, Marina Helena C. G. Magalhães   +3 more
doaj   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Carpal Tunnel Syndrome Associated with Oral Bisphosphonates. A Population-Based Cohort Study.

PLoS ONE, 2016
BackgroundBisphosphonates are widely used to prevent osteoporotic fractures. Some severe musculoskeletal reactions have been described with this medication; among them, some cases of carpal tunnel syndrome.
Alfonso Carvajal, Luis H Martín Arias, María Sáinz, Antonio Escudero, Inmaculada Fierro, Odile Sauzet, Victoria R Cornelius, Mariam Molokhia   +7 more
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

The Effects of Bisphosphonates Used Continually or Intermittently on Fractures, Bone Mineral Density and Biochemical Parameters in Osteoporotic Patients - Original Investigation

Türk Osteoporoz Dergisi, 2010
Aim: The aim of this study was to evaluate the effects of bisphosphonates on new fracture development, bone mineral density and biochemical parameters in osteoporotic patients who were treated with these drugs for 5 years. Material and Methods: Thirty
Alev Çevikol, Ebru Umay, Özgür Zeliha Karaahmet, Özlem Çelik Avluk, Aytül Çakcı   +4 more
doaj  

A Mixed Covalent–Supramolecular Interpenetrated Copper–Phosphonate Network

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
Zigzag Cu–bisphosphonate double strands are connected by dipyridyl linkers to two‐dimensional layers which are organized via hydrogen bonds into a three‐dimensional, two‐fold interpenetrated hydrogen‐bonded framework. A novel copper‐based coordination network [Cu(1,4‐DPB)(H2NBP)] was synthesized via a hydrothermal process using 1,4‐di(pyridin‐4‐yl ...
Marcus N. A. Fetzer, Tobias Heinen, Nabil Assahub, Christoph Janiak   +3 more
wiley   +1 more source

Comprehensive Approach to the Treatment and Prevention of Bisphosphonate-Induced Osteonecrosis of the Jaw

Juvenis Scientia
Osteonecrosis of the jaws (ONJ) is a severe complication associated with the administration of bisphosphonates, drugs used for the treatment of osteoporosis and metastatic bone disease.
Pilipov, I.A., Galstian, S.G., Timofeev, E.V.   +2 more
doaj   +1 more source