Results 41 to 50 of about 52,862 (295)
How Do Bisphosphonates Inhibit Bone Metastasis In Vivo? [PDF]
, 2010 "Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption and have demonstrated clinical utility in the treatment of patients with osteolytic bone metastases.
PIERRICK GERARD JEAN FOURNIER
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Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
Bisphosphonates: Mechanisms of Action
, 2008 The bisphosphonates are a class of drugs used in various diseases of calcium metabolism. This chapter describes the history of the development, chemistry, biological actions, and molecular mechanisms of action of bisphosphonates.
Alfred A. Reszka +4 more
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Advanced Science, EarlyView.Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu +5 more
wiley +1 more source
Bisphosphonate-related bilateral atypical femoral fractures : be aware and beware [PDF]
, 2011 Although bisphosphonates have a well established therapeutic role in the prevention of osteoporosis-related fractures, several reports published over the past 5-6 years suggest a possible causative relationship between long-term use of bisphosphonates ...
Depasquale, Ruben +2 more
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Advanced Science, EarlyView.This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang +9 more
wiley +1 more source
Association of oral bisphosphonates with cardioembolic ischemic stroke: a nested case-control study
Frontiers in Pharmacology, 2023 Background: Bisphosphonates have been reported to increase the risk of atrial fibrillation. Therefore, it is conceivable that they may increase the risk of cardioembolic ischemic stroke (IS).
Sara Rodríguez-Martín +11 more
doaj +1 more source
Advanced Science, EarlyView.Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang +16 more
wiley +1 more source
Prevention of bisphosphonates-induced osteonecrosis [PDF]
, 2007 The osteonecrosis of the jaw is a new emergent disease, secondary to prolonged use of bisphosphonates. Bisphosphonates are a class of drug used in prevention and cure of bone diseases such as malignancy or bone metabolic diseases.
Bellora, Alessandro +3 more
core +1 more source
Denosumab compared to bisphosphonates to treat postmenopausal osteoporosis: a meta-analysis
Journal of Orthopaedic Surgery and Research, 2018 Background The standard treatment for osteoporosis was controversial. Denosumab and bisphosphonates were two most common drugs. The purpose of this study was to compare the efficacy and safety of denosumab with bisphosphonates to treat osteoporosis ...
Jiaqi Wu +3 more
doaj +1 more source