Results 11 to 20 of about 37,214 (250)
Journal of Pharmacy and Bioallied Sciences, 2012 Bisphosphonates are used widely for variety of bone condition, most notably IV bisphosphonates in the treatment of metastic bone lesion and oral bisphosphonates for osteoporosis.
Nalliappan Ganapathy +4 more
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Endocrinology and Metabolism Clinics of North America, 2003 Osteoporosis is the result of bone loss due to an imbalance in bone turnover such that bone resorption exceeds bone formation. Bisphosphonates are potent inhibitors of osteoclast activity that reduce bone turnover and re-establish the balance between bone resorption and formation. In clinical studies, several bisphosphonates prevent bone loss, preserve
Julie T, Lin, Joseph M, Lane
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Bisphosphonates for Osteoporosis [PDF]
New England Journal of Medicine, 2011 Bisphosphonates are compounds characterized by a P-C-P structure. They act essentially on bone, inhibiting bone resorption. Through this mechanism they decrease bone loss, increase bone mineral density, and decrease bone turnover. They are therefore administered in diseases with elevated bone destruction, such as Paget's disease, metastatic bone ...
Vis, M., Dijkmans, B.A.C., Lems, W.F.
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Bisphosphonate nephrotoxicity [PDF]
Kidney International, 2008 Bisphosphonates are valuable agents for the treatment of post-menopausal osteoporosis (PMO), hypercalcemia of malignancy, and osteolytic bone metastases. Oral bisphosphonates are used mainly to treat PMO and are not associated with significant nephrotoxicity.
Perazella, Mark A., Markowitz, Glen S.
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Bisphosphonates and Cancer [PDF]
Journal of Veterinary Internal Medicine, 2004 Abstract Bisphosphonates form a family of drugs characterized pharmacologically by their ability to inhibit bone resorption and pharma-cokinetically by similar intestinal absorption, skeletal distribution, and renal elimination. Two groups of bisphosphonates exist chemically, non-amino-bisphosphates and amino-bisphosphonates.
Rowan J, Milner +5 more
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Annals of the New York Academy of Sciences, 2006 Abstract: Bisphosphonates belong to a class of compounds similar to pyrophosphate. In these compounds the oxygen atom of the pyrophosphate is replaced by a carbon atom resulting in a P‐C‐P bond. They exert a potent inhibitory effect on osteoclasts and are therefore potent antiresorptive agents. They reduce bone turnover, increase bone mineral density,
Lambrinoudaki, I. +2 more
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Long Term Bisphosphonate Use in Osteoporotic Patients; A Step Forward, Two Steps Back
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Bisphosphonates are the main class of drugs widely used in prevention and treatment of osteoporosis. Along with the beneficial effects, recent studies point to the harms of long-term treatment with bisphosphonates. Methods.
Pooneh Salari, Mohammad Abdollahi
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Effect of bisphosphonates on bone giant cell tumor recurrence: a meta-analysis
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background We examined the impact of bisphosphonates as adjuvant therapy on the recurrence of giant cell bone tumors and the impact of various tumor stages and surgical techniques on this effect.
Marwa Mohsen +4 more
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Evaluation of trabecular bone changes according to the type of prosthesis in patients using bisphosphonates: a retrospective study [PDF]
Brazilian Oral Research, 2023 The objective of the study was to retrospectively compare the fractal size values calculated in the trabecular bone according to the type of complete removable denture, removable partial denture, and partial fixed prosthesis between patients using ...
Begüm Ünlü Kurşun, Ender Akan
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Parathyroid hormone versus bisphosphonate treatment on bone mineral density in osteoporosis therapy: a meta-analysis of randomized controlled trials. [PDF]
PLoS ONE, 2011 BACKGROUND: Bisphosphonates and parathyroid hormone (PTH) represent the antiresorptive and anabolic classes of drugs for osteoporosis treatment. Bone mineral density (BMD) is an essential parameter for the evaluation of anti-osteoporotic drugs.
Longxiang Shen +5 more
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