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A highly potent human antibody neutralizing all serotypes of BK polyomavirus. [PDF]
PLoS PathogensBK polyomavirus infection poses a significant risk to kidney transplant recipients. Reactivation of dormant virus in the transplanted kidney, triggered by immunosuppression, can lead to BK polyomavirus-associated nephropathy in up to 10% of transplants ...
Marcel Weber +12 more
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BK Polyomavirus—Biology, Genomic Variation and Diagnosis [PDF]
Viruses, 2021 The BK polyomavirus (BKPyV), a representative of the family Polyomaviridae, is widespread in the human population. While the virus does not cause significant clinical symptoms in immunocompetent individuals, it is activated in cases of immune deficiency,
Jacek Furmaga +7 more
doaj +4 more sources
J Am Soc NephrolMost of the world's adult population is latently infected by the BK polyomavirus. It causes asymptomatic infection in healthy individuals but emerged as a threat to kidney transplant recipients because of virus-associated nephropathy caused by ...
Helle F +5 more
europepmc +3 more sources
BK polyomavirus-associated nephropathy [PDF]
Childhood Kidney Diseases, 2022 BK polyomavirus (BKPyV) is a ubiquitous virus residing in the kidney tubules and is clinically significant only in immunocompromised patients. In clinical practice, BKPyV is a causative pathogen of BKPyV-associated nephropathy (BKVAN) in kidney allograft
Yo Han Ahn, Hee Gyung Kang
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundBK polyomavirus infection results in renal allograft dysfunction, and it is important to find methods of prediction and treatment. As a regulator of host immunity, changes in the gut microbiota are associated with a variety of infections ...
Jian Zhang +6 more
doaj +2 more sources
BK Polyomavirus-associated nephropathy - diagnostic and treatment standard. [PDF]
Nephrol Dial TransplantBK polyomavirus (BKPyV) is recognized as a significant viral complication of kidney transplantation. Prompt immunosuppression reduction reduces early graft failure rates due to BK polyomavirus-associated nephropathy (BKPyVAN), however, modulation of ...
Al-Talib M +3 more
europepmc +2 more sources
BK Polyomavirus in Renal Transplantation: Virological Notes for Monitoring and Diagnosis [PDF]
BiomoleculesPolyomavirus-associated nephropathy was first reported over 50 years ago. However, it still represents a cause of renal injury in kidney transplant recipients, particularly in the first two years post-transplantation, with occurrence rates of 1–10%.
Cristina Costa +3 more
doaj +2 more sources
A Cell Culture Model of BK Polyomavirus Persistence, Genome Recombination, and Reactivation
mBio, 2021 BK polyomavirus (BKPyV) generally establishes a persistent subclinical infection in healthy individuals but can cause severe disease in transplant recipients.
Linbo Zhao, Michael J. Imperiale
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BK Polyomavirus-Associated Nephropathy and Hemorrhagic Cystitis in Transplant Recipients—What We Understand and What Remains Unclear [PDF]
VirusesThe reactivation of BK polyomavirus (BKPyV) during severe immunosuppression plays a crucial role in two significant syndromes observed in transplant recipients: BK polyomavirus-associated nephropathy (BKPyVAN) in kidney transplant patients and BK ...
Tang-Her Jaing +2 more
doaj +2 more sources
Development of a droplet digital PCR assay for the detection of BK polyomavirus [PDF]
Microbiology SpectrumThe objective of this study was to establish a more sensitive and specific diagnostic method for detecting plasma BK polyomavirus (BKPyV) DNA load in patients after renal transplantation using droplet digital polymerase chain reaction (ddPCR) and to ...
Lu Ai +9 more
doaj +2 more sources