Results 11 to 20 of about 2,798 (150)

BK polyomavirus-associated nephropathy [PDF]

Childhood Kidney Diseases, 2022
BK polyomavirus (BKPyV) is a ubiquitous virus residing in the kidney tubules and is clinically significant only in immunocompromised patients. In clinical practice, BKPyV is a causative pathogen of BKPyV-associated nephropathy (BKVAN) in kidney allograft
Yo Han Ahn, Hee Gyung Kang
doaj   +2 more sources

Cellular immunity in BK polyomavirus associated nephropathy following adult kidney transplantation

Transplantation Reports, 2022
Background: BK polyomavirus (BKPyV) is the most important polyomavirus affecting renal transplant recipients. BKPyV associated nephropathy (BKVAN) is seen in about 5% of renal transplant patients and can lead to graft loss in up to 50% of cases ...
Laila Schneidewind, Uwe Grunwald, Desiree L. Dräger, Thomas Neumann, Jennifer Kranz, Oliver W. Hakenberg   +5 more
doaj   +2 more sources

Innate Immunity Response to BK Virus Infection in Polyomavirus-Associated Nephropathy in Kidney Transplant Recipients [PDF]

Transplantology, 2022
BK polyomavirus (BKV) mainly causes infection in uroepithelial and renal tubular epithelial cells of either immunocompetent or immunocompromised hosts.
Wiwat Chancharoenthana, Asada Leelahavanichkul   +1 more
doaj   +2 more sources

Clinical and immunological characteristics for BK polyomavirus-associated nephropathy after kidney transplantation. [PDF]

Immun Inflamm Dis, 2023
AbstractIntroductionBK polyomavirus (BKPyV)‐associated nephropathy (BKPyVAN) can cause a significant risk of allograft impairment after kidney transplantation (KT). Intact BKPyV‐specific immunity is associated with viral containment. This study investigated BKPyV‐specific immunological factors among KT recipients.MethodsThis prospective study in a ...
Siripoon T, Apiwattanakul N, Mongkolrattanakul P, Tongsook C, Unwanatham N, Hongeng S, Kantachuvesiri S, Bruminhent J.   +7 more
europepmc   +5 more sources

Incidence, Risk Factors, and Outcomes of Kidney Transplant Recipients With BK Polyomavirus-Associated Nephropathy. [PDF]

Kidney Int Rep, 2023
BK polyomavirus-associated nephropathy (BKPyVAN) is associated with graft dysfunction and loss; however, knowledge of immunosuppression reduction strategies and long-term graft, and patient outcomes across the disease spectrum is lacking.This cohort study included 14,697 kidney transplant recipients in Australia and New Zealand (2005-2019), followed ...
Gately R, Milanzi E, Lim W, Teixeira-Pinto A, Clayton P, Isbel N, Johnson DW, Hawley C, Campbell S, Wong G.   +9 more
europepmc   +5 more sources

Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement. [PDF]

Ann Transl Med, 2020
This study aimed to investigate the pathological characteristics of BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) with glomerular involvement in kidney transplant recipients.Forty-four patients with glomerular BKPyV infection were retrospectively included for analysis.
Chen XT, Deng RH, Yang SC, Hou XT, Li J, Chen YY, Yang HF, Wang ZY, Wang CX, Qiu J, Chen LZ, Chen WF, Huang G.   +12 more
europepmc   +4 more sources

BK Polyomavirus-associated nephropathy - diagnostic and treatment standard. [PDF]

Nephrol Dial Transplant
ABSTRACT BK polyomavirus (BKPyV) is recognized as a significant viral complication of kidney transplantation. Prompt immunosuppression reduction reduces early graft failure rates due to BK polyomavirus-associated nephropathy (BKPyVAN), however, modulation of immunosuppression can lead to acute rejection.
Al-Talib M, Welberry-Smith M, Macdonald A, Griffin S.   +3 more
europepmc   +5 more sources

Levels of donor-derived cell-free DNA and chemokines in BK polyomavirus-associated nephropathy. [PDF]

Clin Transplant, 2022
AbstractBackgroundBK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers reflecting tissue injury (donor‐derived cell‐free DNA [dd‐cfDNA]) or immune activation (C‐X‐C motif chemokine
Mayer KA, Omic H, Weseslindtner L, Doberer K, Reindl-Schwaighofer R, Viard T, Tillgren A, Haindl S, Casas S, Eskandary F, Heinzel A, Kozakowski N, Kikić Ž, Böhmig GA, Eder M.   +14 more
europepmc   +3 more sources

BK Polyomavirus-Associated Nephropathy Complicated by Life-Threatening Hemorrhagic Pericardial Effusion Following Immunosuppression Reduction in a Kidney Transplant Recipient: A Case Report. [PDF]

Case Rep Transplant
Background BK polyomavirus (BKPyV) is an opportunistic infection following kidney transplantation due to immunosuppression. It is a recognized cause of tubulitis and graft dysfunction in kidney transplant recipients (KTRs). Management is challenging because clinicians must balance viral control with the risk of acute rejection.
Moradi H, Naimi A, Moeinzadeh F.
europepmc   +2 more sources

Endoplasmic Reticulum Stress Mediates Renal Tubular Vacuolation in BK Polyomavirus-Associated Nephropathy. [PDF]

Front Endocrinol (Lausanne), 2022
ObjectiveThis study aimed to explore the molecular mechanism of cytoplasmic vacuolation caused by BK polyomavirus (BKPyV) and thus search for potential target for drug repurposing.MethodsMorphological features of BK polyomavirus-associated nephropathy (BKPyVAN) were studied under light and electron microscopes.
Zhao GD, Gao R, Hou XT, Zhang H, Chen XT, Luo JQ, Yang HF, Chen T, Shen X, Yang SC, Wu CL, Huang G.   +11 more
europepmc   +4 more sources