Results 11 to 20 of about 2,684 (148)

Clinical and immunological characteristics for BK polyomavirus-associated nephropathy after kidney transplantation. [PDF]

Immun Inflamm Dis, 2023
AbstractIntroductionBK polyomavirus (BKPyV)‐associated nephropathy (BKPyVAN) can cause a significant risk of allograft impairment after kidney transplantation (KT). Intact BKPyV‐specific immunity is associated with viral containment. This study investigated BKPyV‐specific immunological factors among KT recipients.MethodsThis prospective study in a ...
Siripoon T, Apiwattanakul N, Mongkolrattanakul P, Tongsook C, Unwanatham N, Hongeng S, Kantachuvesiri S, Bruminhent J.   +7 more
europepmc   +5 more sources

A delicate balance between rejection and BK polyomavirus associated nephropathy; A retrospective cohort study in renal transplant recipients. [PDF]

PLoS ONE, 2017
BackgroundThe immunosuppressive agents mycophenolate acid (MPA) and tacrolimus (Tac) are associated with a higher incidence of BK polyomavirus nephropathy (BKPyVAN).
Lilli Gard, Willem van Doesum, Hubert G M Niesters, Willem J van Son, Arjan Diepstra, Coen A Stegeman, Henk Groen, Annelies Riezebos-Brilman, Jan Stephan Sanders   +8 more
doaj   +5 more sources

Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement. [PDF]

Ann Transl Med, 2020
This study aimed to investigate the pathological characteristics of BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) with glomerular involvement in kidney transplant recipients.Forty-four patients with glomerular BKPyV infection were retrospectively included for analysis.
Chen XT, Deng RH, Yang SC, Hou XT, Li J, Chen YY, Yang HF, Wang ZY, Wang CX, Qiu J, Chen LZ, Chen WF, Huang G.   +12 more
europepmc   +4 more sources

BK Polyomavirus-associated nephropathy - diagnostic and treatment standard. [PDF]

Nephrol Dial Transplant
ABSTRACT BK polyomavirus (BKPyV) is recognized as a significant viral complication of kidney transplantation. Prompt immunosuppression reduction reduces early graft failure rates due to BK polyomavirus-associated nephropathy (BKPyVAN), however, modulation of immunosuppression can lead to acute rejection.
Al-Talib M, Welberry-Smith M, Macdonald A, Griffin S.   +3 more
europepmc   +5 more sources

Levels of donor-derived cell-free DNA and chemokines in BK polyomavirus-associated nephropathy. [PDF]

Clin Transplant, 2022
AbstractBackgroundBK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers reflecting tissue injury (donor‐derived cell‐free DNA [dd‐cfDNA]) or immune activation (C‐X‐C motif chemokine
Mayer KA, Omic H, Weseslindtner L, Doberer K, Reindl-Schwaighofer R, Viard T, Tillgren A, Haindl S, Casas S, Eskandary F, Heinzel A, Kozakowski N, Kikić Ž, Böhmig GA, Eder M.   +14 more
europepmc   +3 more sources

Endoplasmic Reticulum Stress Mediates Renal Tubular Vacuolation in BK Polyomavirus-Associated Nephropathy. [PDF]

Front Endocrinol (Lausanne), 2022
ObjectiveThis study aimed to explore the molecular mechanism of cytoplasmic vacuolation caused by BK polyomavirus (BKPyV) and thus search for potential target for drug repurposing.MethodsMorphological features of BK polyomavirus-associated nephropathy (BKPyVAN) were studied under light and electron microscopes.
Zhao GD, Gao R, Hou XT, Zhang H, Chen XT, Luo JQ, Yang HF, Chen T, Shen X, Yang SC, Wu CL, Huang G.   +11 more
europepmc   +4 more sources

Clinical Relevance of Absolute BK Polyoma Viral Load Kinetics in Patients With Biopsy Proven BK Polyomavirus Associated Nephropathy. [PDF]

Front Med (Lausanne), 2021
Introduction: The absolute BK viral load is an important diagnostic surrogate for BK polyomavirus associated nephropathy (PyVAN) after renal transplant (KTX) and serial assessment of BK viremia is recommended. However, there is no data indicating which particular viral load change, i.e., absolute vs.
Omić H, Kläger JP, Herkner H, Aberle SW, Regele H, Weseslindtner L, Schrag TA, Bond G, Hohenstein K, Watschinger B, Werzowa J, Strassl R, Eder M, Kikić Ž.   +13 more
europepmc   +5 more sources

Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy. [PDF]

J Zhejiang Univ Sci B, 2021
BK polyomavirus-associated nephropathy (BKPyVAN) is a common cause of allograft failure. However, differentiation between BKPyVAN and type I T cell-mediated rejection (TCMR) is challenging when simian virus 40 (SV40) staining is negative, because of the similarities in histopathology. This study investigated whether donor-derived cell-free DNA (ddcfDNA)
Shen J, Guo L, Lei W, Liu S, Yan P, Liu H, Zhou J, Zhou Q, Liu F, Jiang T, Wang H, Wu J, Chen J, Wang R.   +13 more
europepmc   +4 more sources

Cellular immunity in BK polyomavirus associated nephropathy following adult kidney transplantation

Transplantation Reports, 2022
Background: BK polyomavirus (BKPyV) is the most important polyomavirus affecting renal transplant recipients. BKPyV associated nephropathy (BKVAN) is seen in about 5% of renal transplant patients and can lead to graft loss in up to 50% of cases ...
Laila Schneidewind, Uwe Grunwald, Desiree L. Dräger, Thomas Neumann, Jennifer Kranz, Oliver W. Hakenberg   +5 more
doaj   +2 more sources

BK Polyomavirus in Renal Transplantation: Virological Notes for Monitoring and Diagnosis [PDF]

Biomolecules
Polyomavirus-associated nephropathy was first reported over 50 years ago. However, it still represents a cause of renal injury in kidney transplant recipients, particularly in the first two years post-transplantation, with occurrence rates of 1–10%.
Cristina Costa, Francesca Sidoti, Alessandro Bondi, Antonio Curtoni   +3 more
doaj   +2 more sources