Results 21 to 30 of about 2,798 (150)

Clinical Relevance of Absolute BK Polyoma Viral Load Kinetics in Patients With Biopsy Proven BK Polyomavirus Associated Nephropathy. [PDF]

Front Med (Lausanne), 2021
Introduction: The absolute BK viral load is an important diagnostic surrogate for BK polyomavirus associated nephropathy (PyVAN) after renal transplant (KTX) and serial assessment of BK viremia is recommended. However, there is no data indicating which particular viral load change, i.e., absolute vs.
Omić H, Kläger JP, Herkner H, Aberle SW, Regele H, Weseslindtner L, Schrag TA, Bond G, Hohenstein K, Watschinger B, Werzowa J, Strassl R, Eder M, Kikić Ž.   +13 more
europepmc   +5 more sources

Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy. [PDF]

J Zhejiang Univ Sci B, 2021
BK polyomavirus-associated nephropathy (BKPyVAN) is a common cause of allograft failure. However, differentiation between BKPyVAN and type I T cell-mediated rejection (TCMR) is challenging when simian virus 40 (SV40) staining is negative, because of the similarities in histopathology. This study investigated whether donor-derived cell-free DNA (ddcfDNA)
Shen J, Guo L, Lei W, Liu S, Yan P, Liu H, Zhou J, Zhou Q, Liu F, Jiang T, Wang H, Wu J, Chen J, Wang R.   +13 more
europepmc   +4 more sources

Histologic versus Molecular Diagnosis of BK Polyomavirus–Associated Nephropathy [PDF]

Clinical Journal of the American Society of Nephrology, 2006
Although discovered in 1970 the BK virus infections had no significant clinical impact until the emergence of BK virus-associated allograft nephropathy (BKPVAN). Escalating clinical challenges required better diagnostic tools and delineation of uniform criteria for diagnosis.
Cinthia B, Drachenberg, John C, Papadimitriou, Emilio, Ramos   +2 more
openaire   +2 more sources

Glucocorticoids Do Not Enhance BK Polyomavirus Replication in Human Renal Proximal Tubular Epithelial Cells In Vitro. [PDF]

Clin Transl Sci
ABSTRACT BK polyomavirus (BKPyV) infection may lead to BKPyV‐associated nephropathy (BKPyVAN) and subsequent graft loss in kidney transplant recipients. Experimental studies have suggested that glucocorticoids (GCs) may enhance BKPyV replication through a steroid‐responsive element within the viral genome.
Moest WT, Lalai RA, Prins J, de Vries APJ, Wessels E, van Kooten C, Feltkamp MCW, Rotmans JI.   +7 more
europepmc   +2 more sources

Conversion from mycophenolate mofetil to mizoribine in the early stages of BK polyomavirus infection could improve kidney allograft prognosis: a single-center study from China

BMC Nephrology, 2021
Background Some studies have suggested mizoribine (MZR) could inhibit the replication of BK polyomavirus (BKPyV). The purpose of this study was to explore whether conversion from mycophenolate mofetil (MMF) to MZR in the early stages of BKPyV infection ...
Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li, Jinsong Chen   +6 more
doaj   +1 more source

BK virus nephropathy in a heart transplant recipient

Brazilian Journal of Nephrology, 2021
BK virus nephropathy in kidney transplantation is widely recognized as an important cause of graft dysfunction and loss. In the case of transplants of organs other than kidney, BK virus nephropathy in native kidneys has been recognized as a cause of ...
John Fredy Nieto-Ríos, Diego Armando Benavides-Henao, Arbey Aristizabal-Alzate, Carol Morales-Contreras, Diana Carolina Chacón-Jaimes, Gustavo Zuluaga-Valencia, Lina María Serna-Higuita   +6 more
doaj   +2 more sources

BK polyomavirus nephropathy in two kidney transplant patients with distinct diagnostic strategies for BK virus and similar clinical outcomes: two case reports

Journal of Medical Case Reports, 2017
Background BK polyomavirus-associated nephropathy is an important cause of post-transplantation renal failure. We present two cases of BK polyomavirus-associated nephropathy who were submitted to contrasting strategies of clinical follow-up to BK ...
Ana Luisa Figueira Gouvêa, Rachel Ingrid Juliboni Cosendey, Ana Lucia Rosa Nascimento, Fabiana Rabe Carvalho, Andrea Alice Silva, Heleno Pinto de Moraes, Mayra Carrijo Rochael, Rafael Brandão Varella, Stephanie Gomes Almeida, Jorge Reis Almeida, Jocemir Ronaldo Lugon   +10 more
doaj   +1 more source

Persistently high-level polyomavirus BK replication in the absence of renal function abnormalities in a kidney transplant recipient

Microbiologia Medica, 2016
Polyomavirus-associated nephropathy is an important cause of allograft dysfunction and graft loss after kidney transplantation. Even if histological evaluation is the gold standard for graft study and diagnosis of polyomavirus-associated nephropathy, K ...
Antonio Curtoni, Cristina Costa, Maria Messina, Francesca Sidoti, Andrea Piceghello, Gabriele Bianco, Luigi Biancone, Giuseppe Paolo Segoloni, Rossana Cavallo   +8 more
doaj   +1 more source

Urothelial Carcinoma of the Bladder Following BK Virus Infection in a Pediatric Kidney Transplant Recipient. [PDF]

Pediatr Transplant
ABSTRACT Background Urothelial bladder carcinoma is extremely rare in children and its association with BK virus infection remains unclear. Methods We describe the case of an 11‐year‐old girl who developed a urothelial carcinoma of the bladder four years after receiving her first kidney transplant.
Ichas M, Allard L, Harper L, Yacoub M, Madden I, Vérité C, Godron-Dubrasquet A, Harambat J.   +7 more
europepmc   +2 more sources

Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients. [PDF]

Ann Transl Med, 2020
The positive predictive value (PPV) of urinary decoy cells for diagnosing BK polyomavirus associated-nephropathy (BKPyVAN) is low. This study was designed to increase the PPV of urinary decoy cells for diagnosing BKPyVAN in kidney transplant recipients.A total of 105 urine sediment samples from 105 patients with positive BK viruria and decoy cells were
Chen XT, Chen WF, Hou XT, Yang SC, Yang HF, Li J, Deng RH, Huang Y, Nuertai Y, Wang CX, Qiu J, Huang G.   +11 more
europepmc   +4 more sources