Results 71 to 80 of about 2,606 (151)

Risk Factors for the Development of BK Polyomavirus and Treatment Outcomes in Kidney Transplant Recipients: An 8‐Year Retrospective Cohort Study

Nephrology, Volume 30, Issue 6, June 2025.
ABSTRACT Background BKPyV‐DNAemia occurs in up to 30% of kidney transplant recipients (KTRs), with graft‐threatening BKPyV‐nephropathy in up to 10%. Risk factors for BKPyV‐DNAemia, BKPyV‐nephropathy, and associated graft loss are incompletely described.
Alyssa Pradhan, Melanie Wyld, Susan Wan, Rebecca Davis, Kushani Jayasinghe, Kate Wyburn   +5 more
wiley   +1 more source

A Review on JC Virus Infection in Kidney Transplant Recipients

Clinical and Developmental Immunology, 2013
The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue.
Serena Delbue, Mariano Ferraresso, Luciana Ghio, Camilla Carloni, Silvia Carluccio, Mirco Belingheri, Alberto Edefonti, Pasquale Ferrante   +7 more
doaj   +1 more source

A Phase I Study Evaluating Safety and Tolerability of Viral‐Specific T Cells Against BK‐Virus in Adult Kidney Transplant Recipients

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT BK polyomavirus (BKPyV) poses a significant threat to kidney transplant recipients (KTR). Current management primarily involves reducing immunosuppression, which increases the risk of rejection. Cell‐based immunotherapy with virus‐specific T cells (VST) has emerged as an alternative approach for treating BKPyV in KTRs. This single‐center phase
Lucy Ptak, Ross O. Meyers, Olga Radko‐Ganz, Kimberly A. McDowell, Margaret Jorgenson, Maggie Chilsen, Didier Mandelbrot, Jacques Galipeau, Sandesh Parajuli   +8 more
wiley   +1 more source

Transferrin Saturation Can Serve as a Novel Biomarker for Predicting the Occurrence and Development of BK Virus‐Related Nephropathy After Kidney Transplantation

Journal of Medical Virology, Volume 97, Issue 3, March 2025.
ABSTRACT BK polyomavirus reactivation is a common complication after kidney transplantation, affecting the long‐term survival of the transplanted kidney. However, it is unclear whether iron levels affect BKPyV reactivation after kidney transplantation.
Yongchuang Yan, Zhigang Wang, Yonghua Feng, Yang Qiu, Yuanbo Qi, Fumin Cheng, Yi Feng, Di Zhang, Guiwen Feng, Wenjun Shang   +9 more
wiley   +1 more source

BK polyomavirus infection: more than 50 years and still a threat to kidney transplant recipients

Frontiers in Transplantation
BK polyomavirus (BKPyV) is a ubiquitous human polyomavirus and a major infection after kidney transplantation, primarily due to immunosuppression. BKPyV reactivation can manifest as viruria in 30%–40%, viremia in 10%–20%, and BK polyomavirus-associated ...
Sandesh Parajuli, Fahad Aziz, Weixiong Zhong, Arjang Djamali   +3 more
doaj   +1 more source

A Multicenter Application of the 2018 Banff Classification for BK Polyomavirus-associated Nephropathy in Renal Transplantation

Transplantation, 2019
Background. With current immunosuppressive regimens, BK polyomavirus-associated nephropathy (BKPyVAN) is still a matter of concern. Stratification of patients at risk for allograft loss is of uttermost importance to guide treatment choice and assess prognosis.
Bouatou, Yassine, Nguyen, Tri Q., Roelofs, Joris J. T. H., Bemelman, Frederike J., Michielsen, Laura, Goldschmeding, Roel, Kers, Jesper, Florquin, Sandrine   +7 more
openaire   +3 more sources

Tumor Necrosis Factor‐Alpha Inhibits the Replication of Patient‐Derived Archetype BK Polyomavirus While Activating Rearranged Strains

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT To date, no drugs are approved for BK polyomavirus (BKPyV) reactivation, a major cause of nephropathy after kidney transplantation. Recently, tumor necrosis factor‐α (TNF‐α) blockade has been proposed as a promising therapy, however, the effect of TNF‐α on the clinically most common archetype (ww) BKPyV remained unclear.
Lise Lauterbach‐Rivière, Lucia Thuringer, Pascal Feld, Lina Kathrin Toews, Jessica Schüssler, Jonas Klinz, Lars Gläser, Stefan Lohse, Anna Sternjakob, Gilles Gasparoni, Kathrin Kattler‐Lackes, Jörn Walter, Marcel A. Lauterbach, Sven Rahmann, Lars Möller, Michael Laue, Martin Janssen, Michael Stöckle, David Schmit, Danilo Fliser, Sigrun Smola   +20 more
wiley   +1 more source

Cellular Immunity Against BK Polyomavirus in Kidney Transplant Recipients: A Comprehensive Review

Transplant Infectious Disease, Volume 27, Issue 1, January/February 2025.
ABSTRACT BK polyomavirus (BKPyV) is an important opportunistic viral infection that complicates kidney transplantation. Uncontrolled viral replication may result in BKPyV‐associated nephropathy (BKPyVAN), a major cause of premature allograft damage and failure.
Mohammed Al‐Talib, Anna Skaria, Siân Griffin   +2 more
wiley   +1 more source

Immunity to Polyomavirus BK Infection: Immune Monitoring to Regulate the Balance between Risk of BKV Nephropathy and Induction of Alloimmunity

Clinical and Developmental Immunology, 2013
Polyomavirus BK-associated nephropathy (PyVAN) is the main infectious cause of allograft damage after kidney transplantation. A number of studies revealed an association between the presence of BKV-specific cellular immunity and BK viral clearance, with ...
Patrizia Comoli, Michela Cioni, Sabrina Basso, Chiara Gagliardone, Leonardo Potenza, Enrico Verrina, Mario Luppi, Marco Zecca, Gian Marco Ghiggeri, Fabrizio Ginevri   +9 more
doaj   +1 more source

Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system

Brazilian Journal of Infectious Diseases, 2011
BK virus, a double-stranded DNA virus, is a member of the Polyomaviridae family which is known to infect humans. Clinical evidence of disease is mostly encountered in immunosuppressed individuals such as AIDS patients or those who undergo renal or bone ...
Rodrigo Lopes da Silva, M.D.
doaj   +1 more source