Results 31 to 40 of about 2,195 (192)

Impact of pre-graft serology on risk of BKPyV infection post-renal transplantation

Nephrology Dialysis Transplantation, 2021
ABSTRACT Objectives BK polyomavirus-associated nephropathy is a troublesome disease caused by BK polyomavirus (BKPyV) infection in immunocompromised renal graft recipients. There are no effective treatments available, making immunosuppression reduction the only management option.
Dakroub, Fatima, Touzé, Antoine, Abdel Sater, Fadi, Fiore, Toni, Morel, Virginie, Tinez, Claire, Helle, François, François, Catherine, Choukroun, Gabriel, Presne, Claire, Guillaume, Nicolas, Duverlie, Gilles, Castelain, Sandrine, Akl, Haidar, Brochot, Etienne   +14 more
openaire   +4 more sources

Serum IgG antibodies from pregnant women reacting to mimotopes of simian virus 40 large T antigen, the viral oncoprotein [PDF]

, 2017
Simian virus 40 (SV40) large T antigen (LT) coding sequences were revealed in different human samples, whereas SV40 antibodies (Ab) were detected in human sera of cancer patients and healthy individuals, although with a lower prevalence. Previous studies
Casali, Maria V., Destro, Federica, Di Stefano, Mariantonietta, Fiore, Josè R., Greco, Pantaleo, Manfrini, Marco, Martini, Fernanda, Mazzoni, Elisa, Rotondo, John Charles, Scutiero, Gennaro, Tognon, Mauro G., Vesce, Fortunato   +11 more
core   +2 more sources

An Unexpected Surge in Plasma BKPyV Viral Load Heralds the Development of BKPyV-Associated Metastatic Bladder Cancer in a Lung Transplant Recipient With BKPyV Nephropathy

American Journal of Transplantation, 2017
We report a lung transplant recipient who developed BK polyoma virus (BKPyV) DNAemia and BKPyV nephropathy. With careful management of his immunosuppression he achieved significant reduction in BKPyV DNAemia and stabilization of his kidney function. He later developed a high-grade bladder cancer and shortly thereafter he experienced a major upsurge in ...
S, Kuppachi, D, Holanda, M, Eberlein, B, Alexiev, A J, Tyler, M C, Wissel, S B, Kleiboeker, C P, Thomas   +7 more
openaire   +2 more sources

Complete Genome Sequences of BK Polyomavirus Strains from Two Patients with Urinary Tract Infection, Sequenced Using the Ion Torrent Platform. [PDF]

, 2017
BK polyomavirus is an important pathogen in kidney transplant patients. We report here two complete genome sequences, those of isolates CAMB-1035 and CAMB-1055, identified in two urine samples tested for urinary tract infection at a hospital in eastern ...
Crump, Colin, Gharbia, Saheer, Jalal, Hamid, Maddren, Christopher, Misra, Raju, Parmar, Surendra, Ranellou, Kyriaki, Rose, Graham, Wooldridge, David   +8 more
core   +1 more source

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells [PDF]

Viruses, 2020
Reactivation of BK polyomavirus (BKPyV) infection is frequently increasing in transplant recipients treated with potent immunosuppressants and highlights the importance of immune system components in controlling viral reactivation. However, the immune response to BKPyV in general and the role of antiviral cytokines in infection control in particular ...
Tony Fiore, Elodie Martin, Véronique Descamps, Etienne Brochot, Virginie Morel, Lynda Handala, Fatima Dakroub, Sandrine Castelain, Gilles Duverlie, François Helle, Catherine François   +10 more
openaire   +3 more sources

Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen

mSphere, 2017
BK polyomavirus (BKPyV) is a human pathogen first isolated in 1971. BKPyV infection is ubiquitous in the human population, with over 80% of adults worldwide being seropositive for BKPyV.
Linbo Zhao, Michael J. Imperiale
doaj   +1 more source

Risk Factors for the Development of BK Polyomavirus and Treatment Outcomes in Kidney Transplant Recipients: An 8-Year Retrospective Cohort Study. [PDF]

Nephrology (Carlton)
ABSTRACT Background BKPyV‐DNAemia occurs in up to 30% of kidney transplant recipients (KTRs), with graft‐threatening BKPyV‐nephropathy in up to 10%. Risk factors for BKPyV‐DNAemia, BKPyV‐nephropathy, and associated graft loss are incompletely described.
Pradhan A, Wyld M, Wan S, Davis R, Jayasinghe K, Wyburn K.   +5 more
europepmc   +2 more sources

MISSEL: a method to identify a large number of small species-specific genomic subsequences and its application to viruses classification [PDF]

, 2016
Continuous improvements in next generation sequencing technologies led to ever-increasing collections of genomic sequences, which have not been easily characterized by biologists, and whose analysis requires huge computational effort.
Babakir Mina, Muhammed, Bertolazzi, Paola, Cella, Eleonora, Ciccozzi, Massimo, Ciotti, Marco, Felici, Giovanni, Fiscon, Giulia, Giovanetti, Marta, Lo Presti, Alessandra, Pierangeli, Alessandra, Weitschek, Emanuel   +10 more
core   +2 more sources

BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection

Viruses, 2018
In immunosuppressed patients, BKPyV-variants emerge carrying rearranged non-coding control-regions (rr-NCCRs) that increase early viral gene region (EVGR) expression and replication capacity.
Francesco Martelli, Zongsong Wu, Serena Delbue, Fabian H. Weissbach, Maria Chiara Giulioli, Pasquale Ferrante, Hans H. Hirsch, Simone Giannecchini   +7 more
doaj   +1 more source

Longitudinal monitoring of BKPyV miRNA levels in kidney transplant recipients with BKPyV‐related pathology reflects viral DNA levels and remain high in viremia patients after clearance of viral DNA

Transplant Infectious Disease, 2022
AbstractIntroductionIt is unclear whether polyomavirus BK (BKPyV) microribonucleic acid (miRNA) measurement has additional diagnostic and predictive value in kidney transplant recipients (KTR) as compared to current methods of monitoring BKPyV DNA loads.Patients and methodsA retrospective, longitudinal study was performed in 30 KTR with BKPyV viruria ...
Willem B. van Doesum, Lilli Gard, Laura W. D. Knijff, Hubert G. M. Niesters, Willem J. van Son, Coen A. Stegeman, Anke van den Berg, Henk Groen, Jacob van den Born, Annelies Riezebos‐Brilman, Jan Stephan Sanders   +10 more
openaire   +3 more sources