Results 81 to 90 of about 2,195 (192)

Human polyomavirus BKPyV and JCPyV serostatus has no impact on women´s human papillomavirus infection outcome

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionPolyomaviruses have both structural and functional similarities with papillomaviruses. Accordingly, their role in human papillomavirus (HPV) associated malignancies has been studied with conflicting results. Our goal was to disclose any association between BK (BKPyV) and/or JC (JCPyV) polyomavirus serology and HPV data derived from Finnish ...
Hanna K. Laine, Hanna K. Laine, Tim Waterboer, Kari Syrjänen, Seija Grenman, Karolina Louvanto, Karolina Louvanto, Stina Syrjänen, Stina Syrjänen   +8 more
openaire   +6 more sources

Salivary and Serum Cytokine Concentrations in Kidney Transplantation: A Prospective Study

Oral Diseases, Volume 31, Issue 12, Page 3474-3481, December 2025.
ABSTRACT Background Kidney transplant recipients (KTRs) experience immune modulation, which may lead to graft rejection and other adverse outcomes. Although serum cytokines are well‐established systemic immune markers, the role of salivary biomarkers has never been reported in the literature.
Luciano Miziara, Marcio Augusto de Oliveira, Debora Macedo, Ligia Pierrotti, Fabiana Agena, Elias David‐Neto, Aluísio Cotrim Segurado, Rodrigo Zerbinati, Marina Gallottini, Paulo Braz‐Silva, Fabiana Martins   +10 more
wiley   +1 more source

Interferon-alpha and MxA inhibit BK polyomavirus replication by interaction with polyomavirus large T antigen

Biomedical Journal
Introduction: BK Polyomavirus (BKPyV) infection is a common complication in kidney transplant recipients and can result in poor outcomes and graft failure. Currently, there is no known effective antiviral agent.
Hsin-Hsu Wu, Yi-Jung Li, Cheng-Hao Weng, Hsiang-Hao Hsu, Ming-Yang Chang, Huang-Yu Yang, Chih-Wei Yang, Ya-Chung Tian   +7 more
doaj   +1 more source

Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization.

PLoS Pathogens, 2021
The BK polyomavirus (BKPyV) is a ubiquitous human virus that persists in the renourinary epithelium. Immunosuppression can lead to BKPyV reactivation in the first year post-transplantation in kidney transplant recipients (KTRs) and hematopoietic stem ...
Mathieu Sikorski, Flora Coulon, Cécile Peltier, Cécile Braudeau, Alexandra Garcia, Matthieu Giraud, Karine Renaudin, Christine Kandel-Aznar, Steven Nedellec, Philippe Hulin, Julien Branchereau, Joëlle Véziers, Pauline Gaboriaud, Antoine Touzé, Julien Burlaud-Gaillard, Régis Josien, Dorian McIlroy, Céline Bressollette-Bodin, Franck Halary   +18 more
doaj   +1 more source

Novel human polyomaviruses in pregnancy: Higher prevalence of BKPyV, but no WUPyV, KIPyV and HPyV9 [PDF]

Journal of Clinical Virology, 2012
Immunosuppression due to pregnancy may lead to higher susceptibility to infections and reactivation of latent infections, such as BK polyomavirus (BKPyV). There is lack of information about the prevalence of novel human polyomavirus 9 (HPyV9), WU (WUPyV) and KI (KIPyV) during pregnancy.To study whether pregnancy results in higher prevalence of HPyV9 ...
Eszter, Csoma, Tamás, Sápy, Beáta, Mészáros, Lajos, Gergely   +3 more
openaire   +2 more sources

Donor HLA-DQ genetic and functional divergence affect the control of BK polyoma virus infection after kidney transplantation. [PDF]

Sci Adv
BK polyomavirus (BKPyV) infection remains a major concern after kidney transplantation, increasing the risk of graft loss in the absence of specific antiviral agent now available.
Chevalier MF, Allain V, Gras J, Racle J, Villemonteix J, Divard G, Feghoul L, Delaugerre C, Molina JM, Taupin JL, Peraldi MN, Gfeller D, Feray C, Caillat-Zucman S.   +13 more
europepmc   +3 more sources

Towards uncovering polyomavirus-carrying human cancers:pathology and implications for tumorigenesis [PDF]

, 2022
Cancer is one of the leading causes of death in humans worldwide. The most common risk factors for cancer include exposure to chemicals, smoking, alcohol, radiation, and inherited genetic mutations.
Klufah, Faisal Mahdi
core   +2 more sources

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

mSphere
BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and
Janani Durairaj, Océane M. Follonier, Karoline Leuzinger, Leila T. Alexander, Maud Wilhelm, Joana Pereira, Caroline A. Hillenbrand, Fabian H. Weissbach, Torsten Schwede, Hans H. Hirsch   +9 more
doaj   +1 more source

Risk Factors for CMV and BK Infections in an Elderly Veteran Population Following Kidney Transplantation: Implications for Immunosuppression Induction and Management

Biomedicines, 2023
Cytomegalovirus (CMV) and BK Polyomavirus (BKPyV) are the most common opportunistic pathogens following kidney transplantation. We evaluated 102 patients with a median age of 63 at Edward Hines VA Hospital from November 2020 to December 2022. Our primary
Anne Thorndyke, Cara Joyce, Manpreet Samra, Laura Cotiguala, Christine Trotter, Oswaldo Aguirre, W. James Chon, Rupinder Sodhi, Reynold I. Lopez-Soler   +8 more
doaj   +1 more source