Pan-urologic cancer genomic subtypes that transcend tissue of origin [PDF]
, 2017 Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of ...
Bossé, Dominick +9 more
core +2 more sources
Pancancer analysis of DNA methylation-driven genes using MethylMix. [PDF]
, 2015 Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.
Gevaert, Olivier +2 more
core +2 more sources
Cancer Cell International, 2021 Background Bladder cancer (BLCA) is the most common genitourinary tumor but lacks specific diagnostic biomarkers. Recent years have witnessed significant advances in the use and approval of immune checkpoint blockade (ICB) therapy to manage BLCA at ...
YiHeng Du +7 more
doaj +1 more source
BLCA prognostic model creation and validation based on immune gene-metabolic gene combination
Discover Oncology, 2023 Abstract Background Bladder cancer (BLCA) is a prevalent urinary system malignancy. Understanding the interplay of immunological and metabolic genes in BLCA is crucial for prognosis and treatment. Methods Immune/metabolism genes were extracted, their expression profiles ...
Shao-Yu Yue +9 more
openaire +3 more sources
Typing tumors using pathways selected by somatic evolution. [PDF]
, 2018 Many recent efforts to analyze cancer genomes involve aggregation of mutations within reference maps of molecular pathways and protein networks. Here, we find these pathway studies are impeded by molecular interactions that are functionally irrelevant to
Huang, Justin +6 more
core +3 more sources
Identification of autophagy‐related genes signature predicts chemotherapeutic and immunotherapeutic efficiency in bladder cancer (BLCA) [PDF]
Journal of Cellular and Molecular Medicine, 2021 AbstractAutophagy maintains cellular homeostasis by degrading and recycling cytoplasmic components under stress conditions, which is identified to be involved in tumorigenesis and now has been recognized as novel target in cancer treatment. In present study, we gathered total autophagy‐related genes and established an autophagy‐related genes signature (
Rui Cao +5 more
openaire +2 more sources
SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering [PDF]
, 2015 Background: With the advances in high throughput technologies, increasing amounts of cancer somatic mutation data are being generated and made available.
Fierro Gutierrez, Ana Carolina Elisa +3 more
core +2 more sources
Small nucleolar RNAs signature (SNORS) identified clinical outcome and prognosis of bladder cancer (BLCA) [PDF]
Cancer Cell International, 2020 Abstract Background Small nucleolar RNAs (snoRNAs) are a new non-coding RNAs (ncRNAs), which have not been widely investigated and are identified to be involved in tumorigenesis. But the function of snoRNAs in BLCA has not been reported yet. Methods SnoRNAs signature (SNORS)
Rui Cao +4 more
openaire +3 more sources
Journal of Inflammation Research, 2022 Mingde Gao1 *, Qiuxing Yang2 *, Haifei Xu,1 Zhigang Chen,1 Xiaolin Wang,1 Haifeng Guo1 1Department of Urology, Affiliated Tumor Hospital of Nantong University & Nantong Tumor Hospital, Nantong, 226361, People’s Republic of China; 2Department of ...
Gao M +5 more
doaj
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types [PDF]
, 2018 Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Alvaro, Domenico +12 more
core +1 more source