Results 31 to 40 of about 15,201 (184)

Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

open access: yesBMC Cancer, 2019
Background The prognosis of bladder urothelial carcinoma (BLCA) varies greatly among patients, and conventional pathological predictors are generally inadequate and often inaccurate to predict the heterogeneous behavior of BLCA.
Shuxiong Zeng   +11 more
doaj   +1 more source

Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer

open access: yesFrontiers in Immunology, 2023
BackgroundPre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial role in repairing tumor-damaged cells and promoting cell survival. However, the predictive value and biological function of PRPF19 in bladder urothelial carcinoma (BLCA)
YaXuan Wang   +7 more
doaj   +1 more source

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types [PDF]

open access: yes, 2018
Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer.
Alvaro, Domenico   +12 more
core   +1 more source

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics [PDF]

open access: yes, 2018
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types.
A. Abeshouse   +740 more
core   +2 more sources

Dynamic Changes in Myofibroblasts Affect the Carcinogenesis and Prognosis of Bladder Cancer Associated With Tumor Microenvironment Remodeling

open access: yesFrontiers in Cell and Developmental Biology, 2022
Bladder cancer (BLCA) is a tumor that possesses significant heterogeneity, and the tumor microenvironment (TME) plays an important role in the development of BLCA.
YiHeng Du   +9 more
doaj   +1 more source

Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer

open access: yesFrontiers in Genetics, 2021
SHMT2 was overexpressed in many tumors, however, the role of SHMT2 in bladder cancer (BLCA) remains unclear. We first analyzed the expression pattern of SHMT2 in BLCA using the TNMplot, Oncomine, the Cancer Genome Atlas (TCGA), and the Gene Expression ...
Peng Zhang, Qian Yang
doaj   +1 more source

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas [PDF]

open access: yes, 2018
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking.
Abdel-Rahman, Mohamed H.   +740 more
core   +2 more sources

Immunological significance of alternative splicing prognostic signatures for bladder cancer

open access: yesHeliyon, 2022
Background: Bladder cancer (BLCA) is the most common malignant tumor in the genitourinary system, and the complex tumor microenvironment (TME) of BLCA is the main factor in its difficult treatment. Accumulated evidence supports that alternative splicing (
Xinyun Li   +4 more
doaj   +1 more source

Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis [PDF]

open access: yes, 2016
Ultraconserved regions (UCRs) have been shown to originate non-coding RNA transcripts (T-UCRs) that have different expression profiles and play functional roles in the pathophysiology of multiple cancers.
Avitabile, Concetta   +26 more
core   +2 more sources

SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis [PDF]

open access: yes, 2016
Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage.
De Maeyer, Dries   +3 more
core   +2 more sources

Home - About - Disclaimer - Privacy