Results 51 to 60 of about 15,495 (203)
SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis [PDF]
, 2016 Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage.
De Maeyer, Dries +3 more
core +2 more sources
The role of the BLCA-4 nuclear matrix protein in bladder cancer
Postępy Higieny i Medycyny Doświadczalnej, 2017 Bladder cancer (BC) affects usually older people. According to information provided by the National Cancer Registry in 2012. BC was the 4th, in terms of illness, cancer in men and 11th in women. Early diagnosis of bladder cancer is important because detected later has worse prognosis.Diagnosis of bladder cancer is not simple and it is still very ...
Beata, Szymańska, Anna, Długosz
openaire +2 more sources
Immune-related long non-coding RNA signature identified prognosis and immunotherapeutic efficiency in bladder cancer (BLCA) [PDF]
Cancer Cell International, 2020 Abstract Background As bladder cancer was recognized to be immunogenic, dozens of studies have focused on immune biology of BLCA, but little is known about its relationship with the long non-coding RNAs (lncRNAs). Methods LASSO Cox regression model was used to establish ...
Rui Cao +4 more
openaire +3 more sources
CDCOCA: A statistical method to define complexity dependence of co-occuring chromosomal aberrations [PDF]
, 2011 Background Copy number alterations (CNA) play a key role in cancer development and progression. Since more than one CNA can be detected in most tumors, frequently co-occurring genetic CNA may point to cooperating cancer related genes.
Baudis, Michael +3 more
core +1 more source
Frontiers in PharmacologyBackgroundAnoikis disrupts the normal apoptotic process in cells, leading to abnormal proliferation and migration, thereby promoting tumor formation and development.
Yusong Zhou +5 more
doaj +1 more source
Post-transcriptional knowledge in pathway analysis increases the accuracy of phenotypes classification [PDF]
, 2016 Motivation: Prediction of phenotypes from high-dimensional data is a crucial task in precision biology and medicine. Many technologies employ genomic biomarkers to characterize phenotypes.
Acunzo, Mario +5 more
core +3 more sources
Pan-cancer classifications of tumor histological images using deep learning [PDF]
, 2020 Histopathological images are essential for the diagnosis of cancer type and selection of optimal treatment. However, the current clinical process of manual inspection of images is time consuming and prone to intra- and inter-observer variability. Here we
Caruana, Dennis +8 more
core +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
New Cross-Talk Layer between Ultraconserved Non-Coding RNAs, MicroRNAs and Polycomb Protein YY1 in Bladder Cancer [PDF]
, 2016 MicroRNAs (miRNAs) are highly conserved elements in mammals, and exert key regulatory functions. Growing evidence shows that miRNAs can interact with another class of non-coding RNAs, so-called transcribed ultraconserved regions (T-UCRs), which take part
Castaldo, Luigi +10 more
core +2 more sources
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source