Results 71 to 80 of about 957,746 (360)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Interplay between advective, diffusive, and active barriers in Rayleigh-Bénard flow [PDF]

arXiv, 2023
Our understanding of the material organization of complex fluid flows has recently benefited from mathematical developments in the theory of objective coherent structures. These methods have provided a wealth of approaches that identify transport barriers in three-dimensional (3D) turbulent flows.
arxiv  

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Nature Communications, 2018
Magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta-amyloid and tau pathology in animal models of Alzheimer’s disease.
N. Lipsman, Y. Meng, A. Bethune, Yuexi Huang, B. Lam, M. Masellis, N. Herrmann, C. Heyn, I. Aubert, A. Boutet, Gwenn S. Smith, K. Hynynen, S. Black   +12 more
semanticscholar   +1 more source

Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Advancement of science, 2021
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain.
Jia Li, Meng Zheng, O. Shimoni, W. Banks, A. Bush, J. Gamble, B. Shi   +6 more
semanticscholar   +1 more source

N-alkylamides : from plant to brain [PDF]

, 2014
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart, Joshi, Tanmayee, Taevernier, Lien, Tatke, Pratima, Verbeke, Frederick, Veryser, Lieselotte, Wynendaele, Evelien   +6 more
core  

A fruitful fly forward : the role of the fly in drug discovery for neurodegeneration [PDF]

, 2014
AD, Alzheimer’s disease; APP, amyloid precursor protein; BBB, blood brain barrier; GFP, green fluorescent protein; HTS, high-throughput screening; HD, Huntington’s disease; LB, Lewy bodies; PD, Parkinson’s disease; PolyQ, Polyglutamine; RNAi, RNA ...
Briffa, Michelle, Cauchi, Ruben J., Vassallo, Neville   +2 more
core   +1 more source

Astrocyte–Endotheliocyte Axis in the Regulation of the Blood–Brain Barrier [PDF]

, 2021
The evolution of blood–brain barrier paralleled centralisation of the nervous system: emergence of neuronal masses required control over composition of the interstitial fluids.
Pivoriūnas, Augustas, Verkhratsky, Alexei   +1 more
core   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Molecular Medicine
Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects.
Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Mazurek, Fabien Gosselet   +11 more
doaj   +1 more source

Functional morphology of the blood-brain barrier in health and disease

Acta Neuropathologica, 2018
The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular unit, is highly regulated but fragile at the same time.
S. Liebner, R. Dijkhuizen, Y. Reiss, K. Plate, D. Agalliu, G. Constantin   +5 more
semanticscholar   +1 more source