Results 61 to 70 of about 80,969 (285)

CSF/serum ratios: modern approach to assess intrathecal response

Инфекция и иммунитет
CSF/serum ratios are the quotients of protein concentrations between the cerebrospinal fluid and blood serum. This method provides an objective assessment of proteins amount and origin in the cerebrospinal fluid.
Alexandra M. Deomkina, R. F. Sayfullin, A. K. Shakaryan, O. V. Shamsheva   +3 more
doaj   +1 more source

Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood–brain barrier and neurovascular unit

Fluids and Barriers of the CNS, 2021
This editorial discusses advances in brain barrier and brain fluid research in 2020. Topics include: the cerebral endothelium and the neurovascular unit; the choroid plexus; the meninges; cerebrospinal fluid and the glymphatic system; disease states ...
Richard F. Keep, Hazel C. Jones, Lester R. Drewes   +2 more
doaj   +1 more source

Cardiopulmonary Bypass Increases Permeability of the Blood-Cerebrospinal Fluid Barrier [PDF]

The Annals of Thoracic Surgery, 2010
The integrity of the blood-cerebrospinal fluid (CSF) barrier during cardiopulmonary bypass (CPB) with hypothermic circulatory arrest (HCA) has not been systematically studied, especially in children. We tested the hypothesis that the blood-CSF barrier is disrupted by CPB.The study randomized 25 piglets (mean weight, 11 kg) to five groups (5 per group):
Toru, Okamura, Nobuyuki, Ishibashi, David, Zurakowski, Richard A, Jonas   +3 more
openaire   +2 more sources

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Pharmaceutics, 2014
Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter ...
Raj K. Singh Badhan, Marylore Chenel, Jeffrey I. Penny   +2 more
doaj   +1 more source

Posttraumatic Invasion of Monocytes across the Blood—Cerebrospinal Fluid Barrier [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2011
The invasion of inflammatory cells occurring after ischemic or traumatic brain injury (TBI) has a detrimental effect on neuronal survival and functional recovery after injury. We have recently demonstrated that not only the blood-brain barrier, but also the blood-cerebrospinal fluid (CSF) barrier (BCSFB), has a role in posttraumatic recruitment of ...
Joanna, Szmydynger-Chodobska, Nathalie, Strazielle, Jessica R, Gandy, Timothy H, Keefe, Brian J, Zink, Jean-François, Ghersi-Egea, Adam, Chodobski   +6 more
openaire   +2 more sources

Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke, Petra Steinacker, Steffen Halbgebauer, Patrick Oeckl, Geert Mayer, Markus Otto   +5 more
wiley   +1 more source

Enantioselectivity in blood-cerebrospinal fluid barrier permeability of substituted p-phenylenediamine quinones in patients with leptomeningeal metastasis

Ecotoxicology and Environmental Safety
Substituted p-phenylenediamine quinones (PPD-Qs), widespread environmental contaminants arising from rubber antioxidants, exhibit documented toxicity and have been detected in human biological matrices.
Yuxiang Weng, Zebin Fang, Xiaoyi Wang, Sihan Mao, Feng Xiao, Luyuan Zhang, Weijian Fan, Chao Zhang, Ping Lan, Renya Zhan, Kaiyuan Huang, Qingsheng Xu   +11 more
doaj   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source