Results 51 to 60 of about 80,969 (285)

Localization of ZIP14 and ZIP8 in HIBCPP Cells

Brain Sciences, 2020
The blood–cerebrospinal fluid barrier (BCB) is important in maintaining brain manganese (Mn) homeostasis. This barrier consists of a single layer of epithelial cells, connected by tight junctions, that restrict the passage of nutrients to only allow ...
Shannon E. Morgan, Horst Schroten, Hiroshi Ishikawa, Ningning Zhao   +3 more
doaj   +1 more source

HIV-1 is Transported into the Central Nervous System by Trafficking Infected Cells

Pathogens and Immunity, 2023
Background: In this work, we carried out a cross-sectional study examining HIV-1 and HCV free virus concentrations in blood and cerebrospinal fluid (CSF) to determine whether HIV-1 enters the central nervous system (CNS) passively as virus particles or ...
Laura Kincer, Gretja Schnell, Ronald Swanstrom, Melissa Miller, Serena Spudich, Joseph Eron, Richard Price, Sarah Joseph   +7 more
doaj   +1 more source

Supplementary Material for: Blood-Cerebrospinal Fluid Barrier Integrity in Delirium Determined by Q-Albumin

, 2017
Background/Aims: Delirium is a common and serious complication in hospitalised patients and its pathophysiology is incompletely understood. We aimed to examine whether blood-cerebrospinal fluid barrier dysfunction, as measured by Q-albumin (the ratio of ...
Frihagen F. (4159642), Hov K.R. (4159657), Watne L.O. (4159651), Ræder J. (4159648), Berg J.P. (4159654), Wyller T.B. (4159645), Hall R. (4159660)   +6 more
core   +1 more source

Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]

, 2009
BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael, Nimerta Rajwans, Michael Hawkes, Kevin C Kain, Lafferty, Erin I., John, Chandy C, Sornchai Looareesuwan, Srivicha Krudsood, Tangpukdee, Noppadon, Lafferty, Erin I, Looareesuwan Sornchai, Fiona E Lovegrove, Krudsood, Srivicha, John Chandy C., Rajwans, Nimerta, Opoka, Robert, Noppadon Tangpukdee, Hawkes Michael, Lafferty Erin I., Lovegrove Fiona E., Kain, Kevin C, Looareesuwan, Sornchai, Lovegrove, Fiona E., Opoka Robert O., Krudsood Srivicha, Kain, Kevin C., Erin I Lafferty, Kain Kevin C., Robert O Opoka, Lovegrove, Fiona E, Rajwans Nimerta, John, Chandy C., W Conrad Liles, Liles, W. Conrad, Tangpukdee Noppadon, Liles, W Conrad, Chandy C John, Opoka, Robert O, Liles W. Conrad   +38 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Clinical Value of Cerebrospinal Fluid ctDNA in Patients 
with Non-small Cell Lung Cancer Meningeal Metastasis

Chinese Journal of Lung Cancer, 2020
Background and objective The mortality rate of lung cancer meningeal metastasis is extremely high. Circulating tumor DNA (ctDNA) has been confirmed to be contain the genomic alterations present in tumors and has been used to monitor tumor progression and
Kunyu ZHANG, Zhaoxia DAI, Siya LIU, Dan LI, Dafu YANG, Saiqiong CUI   +5 more
doaj   +1 more source

Lipoprotein(a) in the Cerebrospinal Fluid of Neurological Patients with Blood–Cerebrospinal Fluid Barrier Dysfunction [PDF]

Clinical Chemistry, 2006
AbstractBackground: Lipoprotein(a) [Lp(a)] is a recognized pathogenic particle in human plasma, but its presence in the cerebrospinal fluid and its possible role in the central nervous system have not been documented. We tested the hypothesis that apolipoprotein(a) [apo(a)], free or as a component of the Lp(a) particle, can cross the blood ...
PEPE G, CHIMIENTI G, LIUZZI GM, LAMANUZZI BL, NARDULLI M, LOLLI, FRANCESCO, ANGLES CANO E, MATA S.   +7 more
openaire   +6 more sources

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
MacLean, L., Peter G. E. Kennedy (126080), MacLean Lorna, Sternberg, J.M., Sternberg, Jeremy M, Peter G E Kennedy, Hansotto Reiber (126078), Sternberg Jeremy M., Reiber, H., Kennedy Peter G. E., Jeremy M Sternberg, Kennedy, Peter G E, Lorna MacLean, MacLean, Lorna, Lorna MacLean (126077), Jeremy M. Sternberg (126082), Reiber Hansotto, Kennedy, P.G.E., Reiber, Hansotto, Hansotto Reiber   +19 more
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source