Results 31 to 40 of about 80,969 (285)

Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways

Communications Biology, 2022
To understand if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) exchange, CSF turnover, blood-brain barrier function or proteolysis were affected by aging or the presence of β amyloid plaques, Elbert et al.
Donald L. Elbert, Bruce W. Patterson, Brendan P. Lucey, Tammie L. S. Benzinger, Randall J. Bateman   +4 more
doaj   +1 more source

Application of contrast-enhanced magnetic resonance imaging in the assessment of blood-cerebrospinal fluid barrier integrity

, 2021
VERHEGGEN, I.C.M., W. Freeze, J. de Jong, J. Jansen, A. Postma, M. van Boxtel, F. Verhey and W. Backes. The application of contrast-enhanced MRI in the assessment of blood-cerebrospinal fluid barrier integrity.
de Jong, Joost J A, Jansen, Jacobus F A, Verheggen, Inge C M, Backes, Walter H, Jansen, Jacobus F A; id_orcid, Postma, Alida A; id_orcid, van Boxtel, Martin P J, Verhey, Frans R J, Postma, Alida A, Freeze, Whitney M   +9 more
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Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria [PDF]

, 2009
Background Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity.
Liles W Conrad, Kain, Kevin C, Kevin C Kain, Kain Kevin C, Liles, W C, Conroy, Andrea L, Conroy Andrea L, Krudsood Srivicha, Erin I Lafferty, Srivicha Krudsood, Lafferty Erin I, Lovegrove, Fiona E, Lafferty, Erin I, Tangpukdee, Noppadon, Fiona E Lovegrove, W Conrad Liles, Tangpukdee Noppadon, Lovegrove Fiona E, Krudsood, Srivicha, Liles, W Conrad, Andrea L Conroy, Noppadon Tangpukdee   +21 more
core   +1 more source

Case Report: Reduced CSF Orexin Levels in a Patient With Sepsis

Frontiers in Neuroscience, 2021
Sepsis is a potentially lethal condition characterized by systemic inflammation and multiple organ failure, and sepsis-associated encephalopathy (SAE) is an independent risk factor for mortality in patients with sepsis. We previously reported that orexin
Yasuhiro Ogawa, Seioh Ezaki, Nobutake Shimojo, Satoru Kawano   +3 more
doaj   +1 more source

The Connected Steady State Model and the Interdependence of the CSF Proteome and CSF Flow Characteristics

Frontiers in Neuroscience, 2017
Here we show that the hydrodynamic radii-dependent entry of blood proteins into cerebrospinal fluid (CSF) can best be modeled with a diffusional system of consecutive interdependent steady states between barrier-restricted molecular flux and bulk flow of
Fabian Metzger, Daniel Mischek, Frédéric Stoffers   +2 more
doaj   +1 more source

Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease [PDF]

, 2018
International audienceThe barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures display a peculiar ...
Catala, Martin, Jean-François Ghersi-Egea, Strazielle, Nathalie, Doetsch, Fiona, Nathalie Strazielle, Martin Catala, Engelhardt, Britta, Ghersi-Egea, Jean-François, Britta Engelhardt, Silva-Vargas, Violeta, Violeta Silva-Vargas, Fiona Doetsch   +11 more
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The embryonic blood-CSF barrier has molecular elements for specific glucose transport and for the general transport of molecules via transcellular routes.

, 2010
In vertebrates, early brain development takes place at the expanded anterior end of the neural tube, which is filled with embryonic cerebrospinal fluid (E-CSF).
Bueno i Torrens, David, 1965-, Parvas, Maryam, David Bueno, Maryam Parvas   +3 more
core   +1 more source

The blood–cerebrospinal fluid barrier

, 2015
Exposure to organic mercury compounds promotes primarily neurological effects. Although methylmercury is recognized as a potent neurotoxicant, its transfer into the central nervous system (CNS) is not fully evaluated.
Lohren, Hanna, Bornhorst, Julia (Dr.), Galla, Hans-Joachim, Schwerdtle, Tanja (Prof. Dr.)   +3 more
core   +2 more sources

Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus

Frontiers in Cellular Neuroscience, 2020
Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár, Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Shahaf Levin, Alemeh Zamani, Radim Jančálek, Radim Jančálek, Petr Dubový, Marek Joukal   +10 more
doaj   +1 more source

Interferon Crosses Blood-Cerebrospinal Fluid Barrier in Monkeys

Experimental Biology and Medicine, 1975
Interferon was detected in the cerebrospinal fluid (CSF) of monkeys injected iv or im with 30 million units of human leukocyte interferon. The im injection maintained a long-lasting plateau at about 1/30th of the corresponding level of interferon in the serum. Interferon injected into the serum.
D V, Habif, R, Lipton, K, Cantell
openaire   +2 more sources