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Biochemistry (Moscow), 2012
The brain is protected by a physiological blood-brain barrier (BBB) against toxins and some metabolites circulating in the blood. At the same time, the BBB limits penetration into the brain of many neuroactive drugs. Efficient ways to increase BBB permeability for delivery of drugs of different chemical nature into the brain are unknown.
N, Goldstein +7 more
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The brain is protected by a physiological blood-brain barrier (BBB) against toxins and some metabolites circulating in the blood. At the same time, the BBB limits penetration into the brain of many neuroactive drugs. Efficient ways to increase BBB permeability for delivery of drugs of different chemical nature into the brain are unknown.
N, Goldstein +7 more
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Neurosurgery, 1980
The anatomical component of the blood-brain barrier (BBB) has been shown to be the cerebral capillary. These capillary endothelial cells are connected by continuous tight intercellular junctions and under normal conditions do not demonstrate transendothelial channels or pinocytotic vesicles.
M, Pollay, P A, Roberts
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The anatomical component of the blood-brain barrier (BBB) has been shown to be the cerebral capillary. These capillary endothelial cells are connected by continuous tight intercellular junctions and under normal conditions do not demonstrate transendothelial channels or pinocytotic vesicles.
M, Pollay, P A, Roberts
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2016
In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Birgit, Obermeier +2 more
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In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Birgit, Obermeier +2 more
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Drug Discovery Today, 2007
Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this
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Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this
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Extra-Blood-Brain-Barrier Brain Structures
1967Publisher Summary This chapter discusses three extra blood–brain-barrier brain structures that are the area postrema (a.p.), the subcommissural organ (s.c.o.), and the subfornical organ (s.f.o). It presents anatomical, histo- and bio-chemical, pharmacological, and physiological data on the a.p., the s.c.o., and the s.f.o.
W P, Koella, J, Sutin
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Blood-brain barrier biomarkers
The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from ...Juan F, Zapata-Acevedo +3 more
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Blood–brain barrier and brain edema
2012Abstract The function of the blood–brain barrier (BBB) continues to be a diagnostic and therapeutic challenge for physicians treating patients with central nervous system (CNS) malignancies. Despite its physiological importance, only a few clinical studies have specifically addressed the role of the BBB in the biology of brain tumors.
Michael, Platten, Wolfgang, Wick
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Journal of neuroradiology = Journal de neuroradiologie, 1990
The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
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The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
openaire +2 more sources