Results 251 to 260 of about 736,342 (305)
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Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
Nature Medicine, 2019Vascular contributions to cognitive impairment are increasingly recognized1–5 as shown by neuropathological6,7, neuroimaging4,8–11, and cerebrospinal fluid biomarker4,12 studies.
John Ringman, Montagne A, Arthur Toga
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Strategies for delivering therapeutics across the blood–brain barrier
Nature Reviews Drug Discovery, 2021Wandong Zhang +2 more
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From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
Nature Reviews Drug Discovery, 2016William Banks, Banks William A
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Journal of Neuroimmune Pharmacology, 2013
The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs.
Felix, Dyrna +3 more
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The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs.
Felix, Dyrna +3 more
openaire +2 more sources
Chemosphere, 2022
Microplastics (MPs) have been well demonstrated as potential threats to the ecosystem, whereas the neurotoxicity of MPs in mammals remains to be elucidated.
Shan Shan +4 more
semanticscholar +1 more source
Microplastics (MPs) have been well demonstrated as potential threats to the ecosystem, whereas the neurotoxicity of MPs in mammals remains to be elucidated.
Shan Shan +4 more
semanticscholar +1 more source
Development, maintenance and disruption of the blood-brain barrier
Nature Medicine, 2013The interface between the blood circulation and the neural tissue features unique characteristics that are encompassed by the term 'blood-brain barrier' (BBB).
B. Obermeier, R. Daneman, R. Ransohoff
semanticscholar +1 more source
2016
In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Birgit, Obermeier +2 more
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In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Birgit, Obermeier +2 more
openaire +2 more sources
Experimental Eye Research, 1977
The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored.
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The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored.
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Neurosurgery, 1980
The anatomical component of the blood-brain barrier (BBB) has been shown to be the cerebral capillary. These capillary endothelial cells are connected by continuous tight intercellular junctions and under normal conditions do not demonstrate transendothelial channels or pinocytotic vesicles.
M, Pollay, P A, Roberts
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The anatomical component of the blood-brain barrier (BBB) has been shown to be the cerebral capillary. These capillary endothelial cells are connected by continuous tight intercellular junctions and under normal conditions do not demonstrate transendothelial channels or pinocytotic vesicles.
M, Pollay, P A, Roberts
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The Blood–Brain Barrier and Epilepsy
Epilepsia, 2006Summary: During the past several years, there has been increasing interest in the role of the blood–brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to image and study the human cerebrovasculature, and further developments in the research of metabolic deficiencies linked to seizure disorders (e.g., GLUT1 deficiency)
Emily, Oby, Damir, Janigro
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