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The blood–brain barrier: a help and a hindrance
Brain : a journal of neurologyThe blood–brain barrier (BBB) is a specialized vascular structure that protects the brain micro-environment from toxins and pathogens in the blood. At the same time, the BBB presents a significant challenge for drug development, as it restricts the entry
Ruslan Rust +4 more
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Bypassing the blood-brain barrier
Science, 2019The meninges membranes surrounding the brain are an immune-blood-brain interface in homeostasis and ...
Justin, Rustenhoven, Jonathan, Kipnis
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Current Biology
In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coordinating the responses of the organism. To protect its intricate and delicate structure, the CNS is enclosed within the rigid confines of the skull, an effective defence against physical trauma.
Audrey, Chagnot, Axel, Montagne
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In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coordinating the responses of the organism. To protect its intricate and delicate structure, the CNS is enclosed within the rigid confines of the skull, an effective defence against physical trauma.
Audrey, Chagnot, Axel, Montagne
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Blood–brain barrier and brain edema
2012Abstract The function of the blood–brain barrier (BBB) continues to be a diagnostic and therapeutic challenge for physicians treating patients with central nervous system (CNS) malignancies. Despite its physiological importance, only a few clinical studies have specifically addressed the role of the BBB in the biology of brain tumors.
Michael, Platten, Wolfgang, Wick
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Adrenomedullin and the Blood-Brain Barrier
Hormone and Metabolic Research, 2001Adrenomedullin (ADM) is present both in the periphery and brain. In addition to its peripheral effects, this peptide can exert central effects such as decreasing food ingestion. We used multiple-time regression analysis to determine that labeled ADM can cross from blood to brain with an apparent influx constant (K(I)) of 5.83 +/- 1.44 x 10(-4) ml/g-min,
A J, Kastin +3 more
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MIGRAINE AND THE BLOOD-BRAIN BARRIER
The Lancet, 1977The prodromal (cerebral) symptoms of migraine are associated with a fall in cerebral blood-flow (C.B.F.). The suggestion that various circulating vasoactive agents might be the cause of this fall in C.B.F. ignores the contradictory findings that the cerebral vascular bed is normally unresponsive to such agents; but if the blood-barrier is disrupted ...
A M, Harper +3 more
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Goldthioglucose and the blood-brain barrier
Experientia, 1968Apres avoir augmente la permeabilite corticale sang-cerveau chez des rats, on a donne a ces animaux une injection d'aurothioglucose. Aucune lesion due a l'aurothioglucose n'a ete decouverte dans aucun des sites de permeabilite accrue. Les resultats montrent que la production de lesions par l'aurothioglucose n'est pas due a une permeabilite non ...
E A, Arees, J, Mayer
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Development of the blood-brain barrier
Trends in Neurosciences, 1990The microenvironment of the CNS is important for neuronal function, and the blood-brain barrier is involved in its maintenance. The barrier is present in a complex cellular system at the level of the tight junctions between endothelial cells. The unique properties of the endothelial cells in the CNS compared with those present in other organs are not ...
W, Risau, H, Wolburg
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The Blood-Brain Barrier in Hypoxia
International Journal of Sports Medicine, 1992The concept of blood-brain barrier has moved over the past years from a passive and relatively immutable structure to a more dynamic interface between blood and brain tissue. The transport mechanisms regulating this adaptative interface might be considered as the most sensitive elements to change such as hypoxia.
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Laminins and the blood-brain barrier
Matrix BiologyThe blood-brain barrier (BBB) is a dynamic structure that maintains brain homeostasis. BBB breakdown is a key pathological hallmark of almost all neurological diseases. Although the regulation of BBB integrity by different cells has been extensively studied, the function of its non-cellular component-the basal lamina in BBB regulation remains largely ...
Ava Nasrollahi, Yao Yao
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