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Blood-brain barrier biomarkers
The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from ...Juan F, Zapata-Acevedo +3 more
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A blood-brain barrier in a dish
Nature Methods, 2012Codifferentiating human pluripotent stem cells along neural and endothelial lineages provides cues to efficiently generate blood-brain barrier endothelial cells.
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Pathophysiology of the blood-brain barrier
Springer Seminars in Immunopathology, 1996The blood-brain barrier (BBB) is a unique feature of the central nervous system (CNS), which isolates the brain from the external environment and prevents access of the majority of circulating substances in the blood to the brain. The concept of complete isolation of the brain from the rest of the body was coined at the beginning of the 20th century ...
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Drug Discovery Today, 2007
Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this
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Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this
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Strategies for delivering therapeutics across the blood–brain barrier
Nature Reviews Drug Discovery, 2021Wandong Zhang +2 more
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Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
Stroke, 2022Tim Magnus +2 more
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The blood–brain barrier in systemic infection and inflammation
Cellular and Molecular Immunology, 2021Ian Galea
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