Results 221 to 230 of about 370,500 (265)

Bypassing the blood-brain barrier

Science, 2019
The meninges membranes surrounding the brain are an immune-blood-brain interface in homeostasis and ...
Justin, Rustenhoven, Jonathan, Kipnis
openaire   +2 more sources

Blood–brain barrier and brain edema

2012
Abstract The function of the blood–brain barrier (BBB) continues to be a diagnostic and therapeutic challenge for physicians treating patients with central nervous system (CNS) malignancies. Despite its physiological importance, only a few clinical studies have specifically addressed the role of the BBB in the biology of brain tumors.
Michael, Platten, Wolfgang, Wick
openaire   +2 more sources

Adrenomedullin and the Blood-Brain Barrier

Hormone and Metabolic Research, 2001
Adrenomedullin (ADM) is present both in the periphery and brain. In addition to its peripheral effects, this peptide can exert central effects such as decreasing food ingestion. We used multiple-time regression analysis to determine that labeled ADM can cross from blood to brain with an apparent influx constant (K(I)) of 5.83 +/- 1.44 x 10(-4) ml/g-min,
A J, Kastin, V, Akerstrom, L, Hackler, W, Pan   +3 more
openaire   +2 more sources

Laminins and the blood-brain barrier

Matrix Biology
The blood-brain barrier (BBB) is a dynamic structure that maintains brain homeostasis. BBB breakdown is a key pathological hallmark of almost all neurological diseases. Although the regulation of BBB integrity by different cells has been extensively studied, the function of its non-cellular component-the basal lamina in BBB regulation remains largely ...
Ava Nasrollahi, Yao Yao
openaire   +2 more sources

The Blood–Brain Barrier and Epilepsy

Epilepsia, 2006
Summary:  During the past several years, there has been increasing interest in the role of the blood–brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to image and study the human cerebrovasculature, and further developments in the research of metabolic deficiencies linked to seizure disorders (e.g., GLUT1 deficiency)
Emily, Oby, Damir, Janigro
openaire   +2 more sources

Goldthioglucose and the blood-brain barrier

Experientia, 1968
Apres avoir augmente la permeabilite corticale sang-cerveau chez des rats, on a donne a ces animaux une injection d'aurothioglucose. Aucune lesion due a l'aurothioglucose n'a ete decouverte dans aucun des sites de permeabilite accrue. Les resultats montrent que la production de lesions par l'aurothioglucose n'est pas due a une permeabilite non ...
E A, Arees, J, Mayer
openaire   +2 more sources

The Blood-Brain Barrier in Hypoxia

International Journal of Sports Medicine, 1992
The concept of blood-brain barrier has moved over the past years from a passive and relatively immutable structure to a more dynamic interface between blood and brain tissue. The transport mechanisms regulating this adaptative interface might be considered as the most sensitive elements to change such as hypoxia.
openaire   +2 more sources

Insulin and the Blood-Brain Barrier

Current Pharmaceutical Design, 2003
Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions.
Stephen C, Woods, Randy J, Seeley, Denis G, Baskin, Michael W, Schwartz   +3 more
openaire   +2 more sources

Hormones and the blood-brain barrier

Hormone Molecular Biology and Clinical Investigation, 2015
Abstract Hormones exert many actions in the brain, and brain cells are also hormonally active. To reach their targets in brain structures, hormones must overcome the blood-brain barrier (BBB). The BBB is a unique device selecting desired/undesired molecules to reach or leave the brain, and it is composed of endothelial cells forming ...
Richard, Hampl, Marie, Bičíková, Lucie, Sosvorová   +2 more
openaire   +2 more sources

The blood-brain barrier.

Journal of neuroradiology = Journal de neuroradiologie, 1990
The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
openaire   +2 more sources