Results 201 to 210 of about 736,342 (305)

From Cerebrovascular Injury to Brain Cancer: The Role of Blood-Brain Barrier Dysfunction. [PDF]

Biomedicines
Kisiel S, Pawlik M, Niemcewicz WJ, Janicki W, Świerczyńska J, Romanczuk K, Zdanowski R, Borkowska A.   +7 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Glimepiride alleviates blood-brain barrier disruption and neuroinflammation in mice with intracerebral haemorrhage. [PDF]

Ann Med
Zhou H, Wang Q, Liu Y, Zhang X, Chen Y, Guo P, Yong VW, Xue M.   +7 more
europepmc   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Toxic Alpha-Synuclein and the Opening of the Gate: Blood-Brain Barrier Damage and Stepwise Leukocyte Infiltration. [PDF]

Cell Mol Neurobiol
Wójcik P, Culmsee C, Adamczyk A.
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

A zebrafish multimodal toolbox to study the blood-brain barrier in health and disease. [PDF]

Sci Rep
Bakker-van Bugnum N, Snijders EE, Hogendorp EFEE, van Noorden CJF, Lou L, Vanhollebeke M, Vanhollebeke B, Grootemaat AE, van der Wel NN, Schlingemann RO, Klaassen I.   +10 more
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Beyond the Leak: Advanced MRI Assessment of the Blood-Brain Barrier in Neurodegeneration.

Neurodegener Dis
Botta D, Bernetti C, Hutuca I, Ojeda Esparza JF, Sveikata L, Lovblad KO, Kurz FT.   +6 more
europepmc   +1 more source

The Role of Blood-Brain Barrier Disruption in Epilepsy: Mechanisms and Consequences. [PDF]

Neurol Int
Suleymanova E, Karan A.
europepmc   +1 more source