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Overview of the Therapeutic Potential of Aptamers Targeting Coagulation Factors
Aptamers are single-stranded DNA or RNA sequences that bind target molecules with high specificity and affinity. Aptamers exhibit several notable advantages over protein-based therapeutics.
M. Liu, K. Zaman, Y. Fortenberry
semanticscholar +1 more source
Acquired factor V inhibitors in a polytraumatized patient [PDF]
Background. Factor V (FV) inhibitors are a rare disorder reported for the first time about fifty years ago, mostly with the unknown cause. The appearance of FV inhibitors is usually preceded by surgery, infections, administration of antibiotics or ...
Tukić Ljiljana+5 more
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Coagulation abnormalities in renal pathology are associated with a high thrombotic and hemorrhagic risk. This study aims to investigate the hemostatic abnormalities that are related to the interaction between soluble coagulation factors and blood cells ...
Efthimia G. Pavlou+11 more
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Background. Blood component therapy helps in managing patients with reduced hematopoiesis, elevated peripheral destruction of cells, and generalized blood loss (bleeding).
Collince Odiwuor Ogolla+2 more
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The coagulation and contact systems are parts of the innate immune system as they prevent bleeding and dissemination of pathogens and also contribute to microbial killing by inflammatory reactions and the release of antimicrobial peptides.
Sonja Oehmcke-Hecht+8 more
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Evaluation of coagulation factors in fresh frozen plasma treated with riboflavin and ultraviolet light [PDF]
Background/Aim. Pathogen inactivation in blood products using riboflavin and ultraviolet (UV) light represents a proactive approach to blood safety, not only for known infectious agents but also for new ones or not yet recognized as threats to the ...
Antić Ana+3 more
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Introduction: Coagulation disorder is one of the major phenomena following the trauma which can deteriorate the condition of the patients. The aim of this study is to determine some factors predicting the incidence of coagulation disorder among acute ...
Zahra Montazeri+3 more
doaj +1 more source
Viscoelastic coagulation test for liver transplantation [PDF]
Coagulation and transfusion management in patients undergoing liver transplantation is challenging. Proper perioperative monitoring of hemostasis is essential to predict the risk of bleeding during surgery, to detect potential causes of hemorrhage in ...
Sun Young Park
doaj +1 more source
Hydrodynamical activation of blood coagulation in stenosed vessels. Theoretical analysis [PDF]
The mechanisms of hydrodynamical activation of blood coagulation system are investigated in stenosed vessels for a wide range of Reynolds number values (from 10 up to 500).
Aleksey Sergeevich Rukhlenko+2 more
doaj +1 more source
The Impact of Prepartum Platelet Count on Postpartum Blood Loss and Its Association with Coagulation Factor XIII Activity [PDF]
BACKGROUND Postpartum hemorrhage is a leading cause of maternal morbidity and mortality worldwide. Contradictory information exists regarding the relevance of prepartum platelet count on postpartum hemorrhage.
Brun, Romana+6 more
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