Results 31 to 40 of about 340,254 (355)

Blood coagulation factor VIII: An overview

Journal of Biosciences, 2003
Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights current knowledge on selected aspects of FVIII in which both the scientist and the clinician should be ...
G M, Bhopale, R K, Nanda
openaire   +2 more sources

Obscure gastrointestinal bleeding in a patient with factor VII deficiency: a case controlled with tranexamic acid [PDF]

Pediatric Emergency Medicine Journal
Factor VII deficiency is a rare, inherited coagulopathy, which can lead to prolonged bleeding. Here, we present a case report of an adolescent with factor VII deficiency who experienced small bowel bleeding that was successfully treated with tranexamic ...
Kyu Hwa Jeong, Young Bae Choi, Yu Bin Kim   +2 more
doaj   +1 more source

Health technology assessment of pathogen reduction technologies applied to plasma for clinical use [PDF]

, 2016
Although existing clinical evidence shows that the transfusion of blood components is becoming increasingly safe, the risk of transmission of known and unknown pathogens, new pathogens or re-emerging pathogens still persists.
Berrino, Alexandra, Casini, Marina, Cicchetti, Americo, Codella, Paola, Facco, Giuseppina, Fiore, Alessandra, Grazzini, Giuliano, Liumbruno, Giancarlo M., Marano, Giuseppe, Marchetti, Marco, Midolo, Emanuela, Minacori, Roberta, Refolo, Pietro, Romano, Federica, Ruggeri, Matteo, Sacchini, Dario, Spagnolo, Antonio G., Urbina, Irene, Vaglio, Stefania   +18 more
core   +1 more source

EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis. [PDF]

PLoS ONE, 2016
EspP (E. coli secreted serine protease, large plasmid encoded) is an extracellular serine protease produced by enterohemorrhagic E. coli (EHEC) O157:H7, a causative agent of diarrhea-associated Hemolytic Uremic Syndrome (D+HUS).
Kevin H M Kuo, Shekeb Khan, Margaret L Rand, Hira S Mian, Elena Brnjac, Linda E Sandercock, Indira Akula, Jean-Philippe Julien, Emil F Pai, Alden E Chesney   +9 more
doaj   +1 more source

Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris [PDF]

, 2002
Objective: To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency.
Hankey, C.R., Lean, M.E.J., Lowe, G.D.O., Rumley, A., Woodward, M.   +4 more
core   +1 more source

Changes in Blood Viscosity With Synthetic Protease Inhibitors

Journal of Pharmacological Sciences, 2003
We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer.
Masahito Hitosugi, Munehiro Niwa, Tomoyoshi Takahashi, Akira Kurosu, Hirohisa Nihei, Toshiaki Nagai, Shogo Tokudome   +6 more
doaj   +1 more source

Plasmatic and cell-based enhancement by microparticles originated from platelets and endothelial cells under simulated in vitro conditions of a dilutional coagulopathy

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2021
Background Aggressive fluid management and other external factors may lead to hypothermia, acidosis and hemodilution (defined as Lethal Triad, LT) contributing to a trauma-induced coagulopathy (TIC) that worsens patients’ outcomes.
Julia K. Böhm, Nadine Schäfer, Marc Maegele, Birgit Stümpges, Ursula Bauerfeind, Michael Caspers   +5 more
doaj   +1 more source

The use of fibrinogen concentrate for the management of trauma-related bleeding. A systematic review and meta-analysis [PDF]

, 2017
Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in ...
Franchini, Massimo, Liumbruno, Giancarlo M., Marano, Giuseppe, Marietta, Marco, Mengoli, Carlo, Pupella, Simonetta, Vaglio, Stefania   +6 more
core   +1 more source

It Is Written in the Clot: Coagulation Assessment in Severe Burn Injury

European Burn Journal
Background: Coagulopathy in severe burn injury is associated with complications and mortality. Methods: We compared 3 tests (EXTEM, INTEM, FIBTEM) of rotational thromboelastometry (ROTEM), a viscoelastic coagulation assay (VCA), with conventional ...
Eirini Nikolaidou, Andriana Lazaridou, Christina Iasonidou, Alexandra Tsaroucha, Sophia Papadopoulou, Eleni Kaldoudi, Apostolos Sovatzidis, Despoina Kakagia   +7 more
doaj   +1 more source

Mathematical modeling of thrombus formation in idealized models of aortic dissection: Initial findings and potential applications [PDF]

, 2016
Aortic dissection is a major aortic catastrophe with a high morbidity and mortality risk caused by the formation of a tear in the aortic wall. The development of a second blood filled region defined as the “false lumen” causes highly disturbed flow ...
Menichini, C, Xu, XY
core   +1 more source