Results 41 to 50 of about 979,894 (292)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Engineering Highly Cellularized Living Materials via Mechanical Agitation

Advanced Functional Materials, EarlyView.
A mechanical agitation strategy is developed to engineer highly cellularized living materials, achieving cell densities of up to 1 billion cells per milliliter. By precisely tuning properties such as stiffness and toughness in blood clots, the approach is validated in both in vitro and in vivo studies.
Aram Bahmani, Shiyu Liu, Evan Johnston, Weiyi Wan, Xiaoyi Lan, Tianqin Ning, Alexander Nottegar, Ran Huo, Shuaibing Jiang, Jianyu Li   +9 more
wiley   +1 more source

Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection. [PDF]

Viruses, 2022
De Maio F, Rullo M, de Candia M, Purgatorio R, Lopopolo G, Santarelli G, Palmieri V, Papi M, Elia G, De Candia E, Sanguinetti M, Altomare CD.   +11 more
europepmc   +1 more source

Kidney Stone Dissolution By Tetherless, Enzyme‐Loaded, Soft Magnetic Miniature Robots

Advanced Healthcare Materials, EarlyView.
Wireless magnetic robots are developed for kidney stone dissolution. The robots navigate through a urinary tract model from bladder and ureter to renal pelvis with the help of external magnetic fields. The filaments are loaded with urease enzyme which catalyzes urea to carbon dioxide and ammonia, thereby increasing pH to basic regime and supporting ...
Afarin Khabbazian, Lauren Kwong, Aaron Lewis, Erica Liu, Noura Abdelrazec, Anna C. Bakenecker, Nil Fontanals, Guillem Lopez, Samuel Sánchez, Juan Manuel Lopez, Brian Carrillo, Monica Farcas, Chris Kallweit, Alfred C. H. Yu, Mir Behrad Khamesee, Veronika Magdanz   +15 more
wiley   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research

Advanced Healthcare Materials, EarlyView.
Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs, Alexander Stoegner, Mateo G. Vasconez Martínez, Markus M. Schreiner, Melanie Cezanne, Ruth Gruebl‐Barabas, Bettina Rodriguez‐Molina, Juergen Alphonsus, Silvia Hayer, Richard Lass, Iris Gerner, Florien Jenner, Wolfgang Holnthoner, Stefan Toegel, Peter Ertl, Hans P. Kiener, Reinhard Windhager, Mario Rothbauer   +17 more
wiley   +1 more source

Comparative Studies on Blood Coagulation Factor XIII

Experimental Biology and Medicine, 1978
SummaryFactor XIII activity and fibrinogen concentrations were determined in multiple, fresh, platelet-poor plasma samples from 15 species of vertebrates. Factor XIII and fibrinogen levels varied independently. In monkey, rat, cat, horse, pig, sheep, goat, goose, chicken, and turkey plasmas, factor XIII activity ranged from 56 to 96% of that found in ...
S. Lopaciuk, Jan McDonagh, R. P. McDonagh   +2 more
openaire   +3 more sources

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Studies on the Coagulation of Chicken Blood. X. Adsorption Analysis of the chi- and delta-Factor Activities. [PDF]

, 1963
Øyvind Sørbye, Torsten Lundström
openalex   +1 more source

Synthetic Antiferromagnetic Designer Nanodisks for High‐Performance Magnetic Separation

Advanced Healthcare Materials, EarlyView.
Micromagnetic‐modeling‐based design and scalable fabrication of synthetic antiferromagnet (SAF) magnetic disk particles (MDPs) using sputter deposition enable high‐performance magnetic separation. The SAF MDPs achieve high colloidal stability and magnetic responsiveness and enable efficient magnetic separation, outperforming conventional particles ...
Subas Scheibler, Sebastian Habermann, Alexander Gogos, Santiago Helbig, Lukas R. H. Gerken, Anna L. Neuer, Vera M. Kissling, Michal Krupinski, Mohammad Alinezhadfar, Rowena Crockett, Nico Kummer, Erik M. Mayr, Dieter Süss, Hans J. Hug, Inge K. Herrmann   +14 more
wiley   +1 more source