Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide. [PDF]
PLoS ONE, 2011 BACKGROUND: Pro-coagulant membrane microvesicles (MV) derived from platelets and leukocytes are shed into the circulation following receptor-mediated activation, cell-cell interaction, and apoptosis. Platelets are sentinel markers of toll-like receptor 4
Jing Xiong +4 more
doaj +1 more source
Antioxidants, 2022 Platelets play a role in transfusion reaction via reactive oxygen species (ROS) generation and CD40 ligand (CD40L) expression. In this study, we aimed to test the hypothesis that the mixing of packed red blood cells (pRBCs) and washed platelets has a ...
Mei-Hua Hu +3 more
doaj +1 more source
PLATELET TURNOVER AND ATHEROTHROMBOSIS
Атеротромбоз, 2017 Platelets play an important role in initiating atherothrombosis, i.e. the formation of blood clots inside a blood vessel at areas of atherosclerotic vascular injury.
A. V. MAZUROV
doaj +1 more source
Shiga toxin and lipopolysaccharide induce platelet-leukocyte aggregates and tissue factor release, a thrombotic mechanism in hemolytic uremic syndrome. [PDF]
PLoS ONE, 2009 BACKGROUND:Aggregates formed between leukocytes and platelets in the circulation lead to release of tissue factor (TF)-bearing microparticles contributing to a prothrombotic state.
Anne-lie Ståhl +4 more
doaj +1 more source
Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]
, 2018 © The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast +66 more
core +2 more sources
Blood, 1947 Abstract 1. The rate of utilization of blood platelets in radiated, thrombopenic cats has been measured directly. Thrombopenic animals, incapable of significant platelet regeneration, were cross circulated via carotid to carotid anastomoses with normal animals.
JOHN S. LAWRENCE, WILLIAM N. VALENTINE
openaire +1 more source
Therapeutic use of red blood cells and platelets derived from human cord blood stem cells
Stem Cells Translational Medicine, 2021 Red blood cells (RBCs) and platelets derived from stem cells are possible solutions to the increasing demand for blood transfusion. Based on the availability of stem cells, their relatively defined differentiation mechanisms, and the massive exploration ...
Xiaoyan Xie +4 more
doaj +1 more source
Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3 [PDF]
, 2016 Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human ...
Arman, Mònica +5 more
core +4 more sources
Origin of Blood Platelets [PDF]
Nature, 1955 THE conclusion of J. H. Wright1 that blood platelets are detached portions of the cytoplasm of megakaryocytes has been supported by much circumstantial evidence, and is generally accepted2, although unequivocal direct evidence is lacking.
openaire +2 more sources
In vitro-derived platelets: the challenges we will have to face to assess quality and safety
Platelets, 2020 Platelet transfusions are given to patients in hospital who have a low blood platelet count (thrombocytopenia) either because of major bleeding (following trauma or surgery) or because the bone marrow production of platelets is impaired often due to ...
S. Mookerjee +3 more
doaj +1 more source