Results 51 to 60 of about 4,620,115 (383)

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade.

open access: yesBlood, 2015
Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these events drive accelerated thrombosis.
S. Magwenzi   +11 more
semanticscholar   +1 more source

AI-aided multiscale modeling of physiologically-significant blood clots [PDF]

open access: yes, 2022
We have developed an AI-aided multiple time stepping (AI-MTS) algorithm and multiscale modeling framework (AI-MSM) and implemented them on the Summit-like supercomputer, AIMOS. AI-MSM is the first of its kind to integrate multi-physics, including intra-platelet, inter-platelet, and fluid-platelet interactions, into one system. It has simulated a record-
arxiv   +1 more source

Original Effective, Safe Technique of Obtaining Platelet Rich Plasma by Centrifugation of the Blood Plasma in Modified Syringe Containers [PDF]

open access: yes, 2019
The aim: to develop, substantiate an effective and safe technology for producing PRP (platelet rich plasma). To quantify the substrate based on the recommended centrifugation protocols.Materials and methods: the effectiveness of the original harvesting ...
Atanasov, D. (Dmitro)   +1 more
core   +3 more sources

Platelet-leukocyte interactions: immunoregulatory role and pathophysiological relevance

open access: yesМедицинская иммунология, 2022
Blood platelets are the central players in thrombosis and blood coagulation. Moreover, they also exhibit immunoregulatory properties and bridge hemostasis and immunity.
O. V. Pavlov   +3 more
doaj   +1 more source

The incredible journey: From megakaryocyte development to platelet formation [PDF]

open access: yes, 2014
Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets.
Italiano, Joseph E., Machlus, Kellie R.
core   +1 more source

THE BLOOD PLATELETS [PDF]

open access: yesBlood, 1947
Abstract 1. The rate of utilization of blood platelets in radiated, thrombopenic cats has been measured directly. Thrombopenic animals, incapable of significant platelet regeneration, were cross circulated via carotid to carotid anastomoses with normal animals.
William N. Valentine, John S. Lawrence
openaire   +4 more sources

ABO Groups in Blood Platelets [PDF]

open access: yesNature, 1954
IT has been found that suspensions of blood platelets in normal saline are agglutinated by A- B- and O-sera, just as these sera agglutinate red blood cells of the corresponding blood group. It is thus possible to establish four blood groups for the blood platelets, similar to the blood groups in erythrocytes.
D. Nelken, J. Gurevitch
openaire   +5 more sources

Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer

open access: yesOncoTarget, 2015
Purpose: Non-small-cell lung cancers harboring EML4-ALK rearrangements are sensitive to crizotinib. However, despite initial response, most patients will eventually relapse, and monitoring EML4-ALK rearrangements over the course of treatment may help ...
R. J. Nilsson   +22 more
semanticscholar   +1 more source

Platelet number in different anticoagulants as a diagnostic biomarker for increased intestinal permeability

open access: yesPlatelets, 2020
The main pathological process associated to increased intestinal permeability is the translocation of toxic products, predominantly endotoxins/lipopolysaccharide (LPS), from the intestinal tract into the microcirculation.
Mercedes Lopez, Goetz Nowak
doaj   +1 more source

Analysis of platelet-rich plasma extraction variations in platelet and blood components between 4 common commercial kits [PDF]

open access: yes, 2017
Background: Platelet-rich plasma (PRP) has been extensively used as a treatment in tissue healing in tendinopathy, muscle injury, and osteoarthritis. However, there is variation in methods of extraction, and this produces different types of PRP. Purpose:
Bulsara, MK   +4 more
core   +2 more sources

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