Results 51 to 60 of about 4,844,363 (388)
OncoTarget, 2015 Purpose: Non-small-cell lung cancers harboring EML4-ALK rearrangements are sensitive to crizotinib. However, despite initial response, most patients will eventually relapse, and monitoring EML4-ALK rearrangements over the course of treatment may help ...
R. J. Nilsson +22 more
semanticscholar +1 more source
Serotonin reuptake inhibitors and cardiovascular disease [PDF]
, 2005 Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R. +2 more
core +1 more source
Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]
, 2020 Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B. +12 more
core +1 more source
Origin of Blood Platelets [PDF]
Nature, 1955 THE conclusion of J. H. Wright1 that blood platelets are detached portions of the cytoplasm of megakaryocytes has been supported by much circumstantial evidence, and is generally accepted2, although unequivocal direct evidence is lacking.
openaire +2 more sources
Blood Platelets in the Progression of Alzheimer’s Disease
PLoS ONE, 2014 Alzheimer’s disease (AD) is characterized by neurotoxic amyloid-ß plaque formation in brain parenchyma and cerebral blood vessels known as cerebral amyloid angiopathy (CAA).
N. Gowert +16 more
semanticscholar +1 more source
Blood platelet kinetics and platelet transfusion [PDF]
Journal of Clinical Investigation, 2013 The discovery of citrate anticoagulant in the 1920s and the development of plastic packs for blood collection in the 1960s laid the groundwork for platelet transfusion therapy on a scale not previously possible. A major limitation, however, was the finding that platelet concentrates prepared from blood anticoagulated with citrate were unsuitable for ...
openaire +2 more sources
Advances in the application of lyophilized platelets and derivative products
Zhongguo shuxue zazhi, 2023 Platelets are important components of the blood system. There are many kinds of concentrated platelets and their derivatives, among which platelet-rich plasma (PRP ), growth factors (GFs) and platelet-rich fibrin (PRF) have been widely used in clinical ...
Wenjuan LI, Shuchao ZHANG
doaj +1 more source
Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]
, 2015 BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G +4 more
core +1 more source
Journal of Lipid Research, 1997 The objective of this study was to determine the transcellular metabolism of leukotriene A4 by rabbit blood cells. mixed peripheral blood leukocyte preparations with and without platelets in a ratio of 1:40 were challenged with the Ca(2+)-ionophore ...
A Sala, T Testa, F Nobili, G Folco
doaj +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source