Results 161 to 170 of about 57,891 (288)

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

open access: yesSmall, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga   +16 more
wiley   +1 more source

Enhanced through‐bond energy transfer‐based bioorthogonal probe enables catalytic‐amplified and sensitive detection of microRNA‐21 for clinical lung cancer diagnosis

open access: yesSmart Molecules, EarlyView.
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li   +10 more
wiley   +1 more source

Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read nanopore sequencing. [PDF]

open access: yesNat Commun
Pastore S   +8 more
europepmc   +1 more source

‘Pro‐Germans in the Pulpits’: The Queensland Presbyterian Church and the Great War

open access: yesJournal of Religious History, EarlyView.
During World War I, Protestant churches in Australia, on the whole, enthusiastically supported the war effort. The Queensland Presbyterian Church was a significant exception. This study analyses discord and tensions among its clergymen about what constituted an appropriate response to the war.
Mark Cryle
wiley   +1 more source

Sex‐Specific Involvement of Gut Microbiota in Behavioral and Endocrine Responses to Chronic Predator Odor in Brandt's Voles

open access: yesIntegrative Zoology, EarlyView.
18 days of predator odor exposure altered gut microbiota, increased anxiety‐like behaviors, and elevated hypothalamic–pituitary–adrenal axis activity in Brandt's voles, with males showing behavioral habituation and females remaining sensitive. Cecal microbiota transplantation experiments confirmed that only female recipients of microbiota from predator‐
Chen Gu   +6 more
wiley   +1 more source

LncRNA TUG1 promotes hypertrophic scar formation via the miR-627/IGF1R axis. [PDF]

open access: yesJ Mol Histol
Bai Z   +9 more
europepmc   +1 more source

Consistent Choice of Prey Source Habitat Across Diverse Landscapes by a Selective Insectivorous Bat

open access: yesIntegrative Zoology, EarlyView.
After analyzing the diet of the greater horseshoe bats in three distinct colonies, we identified significant spatial and temporal differences, particularly noting a stronger reliance on riparian habitats in Mediterranean areas. The species exhibits great ecological adaptability with strong plasticity in prey source habitats, shifting preferences among ...
Miren Aldasoro   +7 more
wiley   +1 more source

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