Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
PLoS Biology, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +2 more sources
Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7 [PDF]
Biochemical Journal, 2015 Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during diabetic nephropathy (DN) has been suggested to be binding and ...
Church, Rachel H. +12 more
openaire +5 more sources
Application of BMP in Bone Tissue Engineering
Frontiers in Bioengineering and Biotechnology, 2022 At present, bone nonunion and delayed union are still difficult problems in orthopaedics. Since the discovery of bone morphogenetic protein (BMP), it has been widely used in various studies due to its powerful role in promoting osteogenesis and ...
Liwei Zhu +9 more
semanticscholar +1 more source
The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis
Gastroenterology, 2020 Background & AIMS Cancer-associated fibroblasts (CAFs), key constituents of the tumor microenvironment, either promote or restrain tumor growth.
Hiroki Kobayashi +35 more
semanticscholar +1 more source
BMP‐2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP/TAZ
Advancement of science, 2020 Growth factors and mechanical cues synergistically affect cellular functions, triggering a variety of signaling pathways. The molecular levels of such cooperative interactions are not fully understood.
Q. Wei +14 more
semanticscholar +1 more source
BMP and BMP receptor expression during murine organogenesis [PDF]
Gene Expression Patterns, 2009 Cell-cell communication is critical for regulating embryonic organ growth and differentiation. The Bone Morphogenetic Protein (BMP) family of transforming growth factor beta (TGFbeta) molecules represents one class of such cell-cell signaling molecules that regulate the morphogenesis of several organs.
Shahab M, Danesh +4 more
openaire +2 more sources
Improving Inter-Laboratory Reproducibility in Measurement of Biochemical Methane Potential (BMP)
Water, 2020 Biochemical methane potential (BMP) tests used to determine the ultimate methane yield of organic substrates are not sufficiently standardized to ensure reproducibility among laboratories. In this contribution, a standardized BMP protocol was tested in a
S. Hafner +3 more
semanticscholar +1 more source
Water Science and Technology, 2023 There is an increasing interest in integrating aerobic granular sludge (AGS) technology into wastewater industries. Several projects are being performed to cultivate the aerobic granules for continuous flow reactors (AGS-CFR), while there is a scarcity ...
Salahaldeen Dababat +3 more
doaj +1 more source
Changes of BMP-2 and BMP-4 in early phase of sepsis [PDF]
Jichu yixue yu linchuang, 2022 Objective To study the change of serum bone morphogenetic protein (BMP)-2 and BMP-4 during the development of sepsis and its mechanisms. Methods Blood was collected for quantifying serum BMP-2 and BMP-4 from patients with sepsis (sepsis group), patients ...
WEN Yan, LIN Jin-can, HUANG Ying-hong, XIAO Wen-biao, ZHANG Min-wei, LIN Jian-dong
doaj +1 more source
Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
, 2014 Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Campbell, David +7 more
core +3 more sources