Results 131 to 140 of about 52,292 (275)

Synapse Elimination Triggered by BMP4 Exocytosis and Presynaptic BMP Receptor Activation

Cell Reports, 2018
In vitro screening of signaling molecules involved in neural circuit formation has identified a large number of synaptogenic proteins. However, factors that drive synapse elimination remain elusive. Here, we report that bone morphogenetic protein 4 (BMP4)
Takahito Higashi, Shinji Tanaka, Tadatsune Iida, Shigeo Okabe   +3 more
doaj   +1 more source

MicroRNA-378 promotes myogenic differentiation by targeting BMP4

Molecular Medicine Reports, 2016
MicroRNA-378 (miRNA-378) has been reported to have a crucial role in skeletal muscle differentiation; however, the underlying mechanisms have largely remained to be elucidated. The present study employed high‑throughput RNA sequencing to investigate the transcriptome following transfection of miRNA‑378 mimics or control RNAs into C2C12 myoblast cells ...
Huiming, Ju, Yuefei, Yang, Anzhi, Sheng, Yuyu, Qi   +3 more
openaire   +3 more sources

WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4 [PDF]

Proceedings of the National Academy of Sciences, 2013
Inability to recruit new adipose cells following weight gain leads to inappropriate enlargement of existing cells (hypertrophic obesity) associated with inflammation and a dysfunctional adipose tissue. We found increased expression of WNT1 inducible signaling pathway protein 2 (WISP2) and other markers of WNT activation in human abdominal s.c.
Ann, Hammarstedt, Shahram, Hedjazifar, Lachmi, Jenndahl, Silvia, Gogg, John, Grünberg, Birgit, Gustafson, Eva, Klimcakova, Vladimir, Stich, Dominique, Langin, Markku, Laakso, Ulf, Smith   +10 more
openaire   +2 more sources

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer

Clinical Cancer Research, 2017
Purpose: Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis.
Victor G. Martinez, Carolina Rubio, M. Martínez-Fernández, C. Segovia, Fernando F. López-Calderón, M. Garin, A. Teijeira, E. Munera-Maravilla, A. Varas, R. Sacedón, Félix Guerrero, F. Villacampa, Federico de la Rosa, D. Castellano, E. López-Collazo, J. Paramio, Á. Vicente, M. Dueñas   +17 more
semanticscholar   +1 more source

miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling

Journal of Orthopaedic Surgery and Research, 2020
Background Atrophic non-union fractures show no radiological evidence of callus formation within 3 months of fracture. microRNA dysregulation may underlie the dysfunctional osteogenesis in atrophic non-union fractures.
Hui Xie, Ming Liu, Yaofen Jin, Haiqing Lin, Yushan Zhang, Song Zheng   +5 more
semanticscholar   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

bioRxiv, 2019
BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is not known whether these heterodimers signal in vivo. To test this, we generated knock in mice carrying a mutation (Bmp7R-GFlag) that prevents proteolytic activation ...
Hyung-Seok Kim, Judith M. Neugebauer, Autumn M. Mcknite, A. Tilak, J. Christian   +4 more
semanticscholar   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source