Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b.
PLoS Genetics, 2019 During vertebrate early embryogenesis, the ventral development is directed by the ventral-to-dorsal activity gradient of the bone morphogenetic protein (BMP) signaling.
Ding Ye +7 more
doaj +1 more source
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
International Journal of Biological Sciences, 2012 Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in a vast majority of cellular processes and is fundamentally important throughout life.
Guiqian Chen, Chuxia Deng, Yi-Ping Li
doaj
The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease
Scientific Reports, 2020 Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear.
Timothy E. Thayer +25 more
doaj +1 more source
S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model
Disease Models & Mechanisms, 2017 The S113R mutation (c.339T>G) (MIM #603690.0001) in SLC33A1 (MIM #603690), an ER membrane acetyl-CoA transporter, has been previously identified in individuals with hereditary spastic paraplegia type 42 (SPG42; MIM #612539).
Pingting Liu +7 more
doaj +1 more source
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]
, 2012 Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine +2 more
core +3 more sources
Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]
, 2014 Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M +6 more
core +3 more sources
ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney
FEBS Open Bio, 2015 Mutations in ABCC6 (ATP‐binding cassette, subfamily C, member 6), an orphan transporter expressed in the liver, are the cause of pseudoxanthoma elasticum.
Ana M. Blazquez-Medela +6 more
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Разработка информационной системы планирования энергоресурсов производственного предприятия OOO "Завод ТехноНИКОЛЬ-Сибирь" [PDF]
, 2012 OBJECTIVE: The expression of bone morphogenetic proteins (BMPs) is enhanced in human atherosclerotic and calcific vascular lesions. While genetic gain- and loss-of-function experiments in mice have supported a causal role of BMP signaling in ...
Aikawa, Elena +8 more
core +1 more source
A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling [PDF]
, 2010 In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilizing human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven.
Eyckmans, Jeroen +3 more
core +1 more source
eLifeBMP signaling has a conserved function in patterning the dorsal-ventral body axis in Bilateria and the directive axis in anthozoan cnidarians. So far, cnidarian studies have focused on the role of different BMP signaling network components in regulating ...
Paul Knabl +7 more
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