Results 171 to 180 of about 114,435 (209)
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Science Signaling, 2002
Cytokines of the transforming growth factor-β (TGF-β) superfamily transduce their signals by activating receptor-regulated Smads (R-Smads). Distinct R-Smads or combinations of R-Smads are activated by TGF-β, activin, or bone morphogenetic proteins (BMPs).
Kohei, Miyazono, Keiji, Miyazawa
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Cytokines of the transforming growth factor-β (TGF-β) superfamily transduce their signals by activating receptor-regulated Smads (R-Smads). Distinct R-Smads or combinations of R-Smads are activated by TGF-β, activin, or bone morphogenetic proteins (BMPs).
Kohei, Miyazono, Keiji, Miyazawa
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BMP Signaling in Skeletogenesis
2010Bone is a dynamic tissue that provides skeletal support to the body and is essential in the maintenance of hematopoiesis and calcium homeostasis. Bone development and remodeling are tightly regulated by local paracrine factors and systemic hormones.
Kristine D. Estrada, Karen M. Lyons
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Modulation of activin and BMP signaling
Molecular and Cellular Endocrinology, 2004Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related types I and II receptors. Here, we summarize recent advances in understanding the mode of action of activins and BMPs, focusing on our elucidation of the crystal structure of BMP-7 in complex with the extracellular ...
Craig A, Harrison +5 more
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BMP Signaling and Iron Homeostasis
The FASEB Journal, 2022Iron is an essential nutrient that is critical for fundamental cellular and organismal processes including oxygen transport and energy generation. However, excess iron can catalyze the formation of toxic free oxygen radicals. Cellular and systemic iron homeostasis are therefore tightly regulated to titrate the iron supply to match iron needs.
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[Regulation of BMP signaling].
Clinical calcium, 2006Bone morphogenetic proteins (BMPs), members of transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and -independent pathways. Intracellular signaling of BMPs is regulated by various modifiers and post-transcriptional modifications including ...
Takeshi, Imamura +2 more
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The role of SMADS in BMP signaling
Frontiers in Bioscience, 2003Bone morphogenetic proteins, BMPs, are members of the transforming growth factor-beta (TGF-beta) superfamily, which are implicated in embryogenesis, organogenesis, skeletogenesis, osteogenesis, cellular differentiation and apoptosis by regulating the expression of specific target genes.
Riko, Nishimura +6 more
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Modulation of BMP signalling by integrins
Biochemical Society Transactions, 2016The bone morphogenetic protein (BMP) pathway is a major conserved signalling pathway with diverse roles in development and homeostasis. Given that cells exist in three-dimensional environments, one important area is to understand how the BMP pathway operates within such complex cellular environments.
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Arginine Methylation Derepresses BMP Signaling
Science Signaling, 2013BMP-dependent arginine methylation of the inhibitor Smad6 leads to activation of the effector proteins Smad1 and Smad5.
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BMP Signaling in Regenerative Medicine
2013More than 40 years after the discovery of Bone Morphogenetic Proteins (BMPs) as bone inducers, a whole protein family of growth factors connected to a wide variety of functions in embryonic development, homeostasis, and regeneration has been characterized.
Julia Zimmer +3 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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