Unanswered Questions Regarding Sex and BMP/TGF-β Signaling
Journal of Developmental Biology, 2018 Crosstalk between the BMP and TGF-β signaling pathways regulates many complex developmental processes from the earliest stages of embryogenesis throughout adult life. In many situations, the two signaling pathways act reciprocally. For example, TGF-&
Tapan A. Shah, Melissa B. Rogers
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Direct response elements of BMP within the PV.1A promoter are essential for its transcriptional regulation during early Xenopus development. [PDF]
PLoS ONE, 2011 Xvent homeobox genes encode transcription factors that repress organizer genes and are essential for dorsoventral specification during early embryogenesis in Xenopus.
Hyun-Shik Lee +10 more
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Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]
, 2019 BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran +5 more
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The early stages of heart development: insights from chicken embryos [PDF]
, 2016 The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan +19 more
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Inferring spatial and signaling relationships between cells from single cell transcriptomic data. [PDF]
, 2020 Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by ...
Cang, Zixuan, Nie, Qing
core
TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals. [PDF]
, 2019 The gut microbiota contributes to host health and fitness, and imbalances in its composition are associated with pathology. However, what shapes microbiota composition is not clear, in particular the role of genetic factors.
Berg, Maureen +5 more
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BMP signaling and stem cell regulation
Developmental Biology, 2005 Stem cells play an essential role in cellular specialization and pattern formation during embryogenesis and in tissue regeneration in adults. This is mainly due to a stem cell's ability to replenish itself (self-renewal) and, at the same time, produce differentiated progeny. Realization of these special stem cell features has changed the prospective of
Zhang, Jiwang, Li, Linheng
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An inwardly rectifying K+ channel is required for patterning. [PDF]
, 2012 Mutations that disrupt function of the human inwardly rectifying potassium channel KIR2.1 are associated with the craniofacial and digital defects of Andersen-Tawil Syndrome, but the contribution of Kir channels to development is undefined.
Bates, Emily +6 more
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Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis [PDF]
, 2014 Molecules associated with TGF-β superfamily such as BMPs and TGF-β are key regulators of inflammation, apoptosis and cellular transitions. Here, we demonstrate that the BMP receptor activin–like kinase 3 (Alk3) is elevated early in response to kidney ...
Basukonda, Dattatreyamurty +14 more
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BMP signaling in the nephron progenitor niche [PDF]
Pediatric Nephrology, 2011 Bone morphogenic proteins (BMPs) play diverse roles in embryonic kidney development, regulating essential aspects of both ureteric bud and nephron development. In this review, we provide an overview of reported expression patterns and functions of BMP signaling components within the nephrogenic zone or nephron progenitor niche of the developing kidney.
Leif, Oxburgh +3 more
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