Results 171 to 180 of about 45,848 (279)

Targeting TLR4/non-canonical NF-κB pathway by Bushen Bitong recipe enhances BMSCs-based cartilage repair in osteoarthritis. [PDF]

Biochem Biophys Rep
Xiang W, Xiang C, Islam A, Yi L, Ouyang Z, Fang R.   +5 more
europepmc   +1 more source

Extracellular Vesicle‐Mediated Communication Between Anterior Cruciate Ligament and Bone Marrow Cells Modulates Hamstring Tenocyte Behavior and Apoptosis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT Following anterior cruciate ligament (ACL) reconstruction, enhancing hamstring tenocyte activity and minimizing apoptosis are critical for preventing graft failure and promoting ligamentization. This study investigated the therapeutic potential of extracellular vesicles (EVs) derived from a coculture of ACL remnant cells and bone marrow ...
Hon‐Lok Lo, Shih‐Hao Huang, Ting‐Hsuan Dai, Shun‐Cheng Wu, Cheng‐Jung Ho, Cheng‐Chang Lu   +5 more
wiley   +1 more source

Senescent BMSC-Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin-Mediated Mitophagy in Macrophages. [PDF]

Aging Cell
Xing Y, Su J, Lin Y, Huang N, Zhang S, Zhou Y, Lu J, Chen W, He K, Yuan W, Li Y, Zheng G, Hu P, Wu D, Ou Y, Chen J.   +15 more
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Targeting N¹-methyladenosine modification in osteoblasts through tRNA methyltransferase 10C reverses mitochondrial dysfunction and ameliorates osteoporosis. [PDF]

Signal Transduct Target Ther
Sun H, Wang W, Zhang C, Zhang T, Yang X, Feng Y, Shan L, Yang Z, Zhang Y, Liu S, Wang W, Wang J, Hou X, Feng S.   +13 more
europepmc   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

A Study on Traceable Oxygen-Releasing Microspheres in Combination with Bone Marrow Mesenchymal Stem Cells to Enhance Skin Wound Healing. [PDF]

Int J Mol Sci
Wang Q, Li X, Xu Q, Xie Y, Duan W, Ma Z, Chen X.   +6 more
europepmc   +1 more source

Size-Dependent Layered Double Hydroxide Nanoparticles Promote Osteogenesis and Bone Regeneration via METTL3-Dependent N6-Methyladenosine Modification of Runx2 mRNA. [PDF]

Int J Nanomedicine
Zhu Y, Sun W, Huang Y, Li J, Jiang H, Luo C, Wan F, Zhou Z.   +7 more
europepmc   +1 more source

Immunomodulatory cytoskeleton of bionic periosteum affects mitochondrial dynamics to promote osteogenesis. [PDF]

Bioact Mater
Zhou T, Ni Z, Huang Y, Huang Z, Guo Q, Wu J, Zhu H, Jiang X, Zhou L, Wang W, Xi K, Gu Y, Cui W, Chen L.   +13 more
europepmc   +1 more source

Exosomes derived from BMSCs regulate macrophage M1/M2 polarization and promoting tendon-bone healing through circRNA1052. [PDF]

Stem Cell Res Ther
Wang G, Xu J, Chen Z, Wang Z, Lin Y, Xu X, Lu Q, Xu Q, Sun Y, Chen L, Xu L, Li X, Wu F.   +12 more
europepmc   +1 more source