Results 161 to 170 of about 45,848 (279)

The miR-212-3p/transferrin axis promotes bone regeneration by modulating iron homeostasis through Schwann cell Exosome-BMSCs communication. [PDF]

Bioact Mater
Jia Y, Li N, Tang D, Pu W, Feng Z, Duan Y, Zhu Y, Wang J, Luo X, Zhang J.   +9 more
europepmc   +1 more source

Wear Rate, Particle Morphology, and Biocompatibility of Polyether‐Ether‐Ketone Femoral Heads Against Highly Cross‐Linked Polyethylene Acetabular Cups in Hip Prosthetic Couples

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
Graphical abstract summarizing the wear performance, particle characterization, and biocompatibility evaluation of PEEK‐on‐HCLPE hip prosthesis components using a hip wear simulator and in vitro immunological assays. ABSTRACT Biological reactions to wear particles from artificial joint prostheses can lead to osteolysis, ultimately resulting in aseptic ...
Fei Hu, Xinyue Zhang, Xiaobo Wu, Zhuocheng Lyu, Xu Zheng, Linjun Yang, Zikai Hua, Dekun Zhang, You Wang   +8 more
wiley   +1 more source

Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury. [PDF]

J Mol Histol
Yu Y, Fang M, Shen C.
europepmc   +1 more source

Extracellular Vesicles in Acute Myeloid Leukemia: Opportunities and Obstacles for Therapeutic Advancement

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation and blocked maturation of hematopoietic stem and progenitor cells. Despite progress in its clinical management, many patients continue to relapse or show limited response to standard therapies, emphasizing the need for novel, safe, and more effective targeted ...
Rongrong Hu, Zaker Ataullev, Luping Lou
wiley   +1 more source

Engineered bone-targeting <i>Lycium barbarum L.</i>-derived extracellular vesicle-like nanoparticles deliver miR167a-5p to regulate mitochondrial dynamics and metabolic reprogramming in alleviating osteoporosis. [PDF]

Mater Today Bio
Chen S, Qin M, Zhao Q, Tian N, Yu L, Shao L, Yan S, Ding X, Sun P, Ma P, Wang J, Fang P, Min W.   +12 more
europepmc   +1 more source

Camouflage Protein‐Engineered Extracellular Vesicles Alleviate TMJ‐OA by Hijacking Caspase‐1 to Suppress Pyroptosis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Temporomandibular joint osteoarthritis (TMJ‐OA) is highly prevalent with an insidious onset. Severe inflammation and significant degenerative changes are often associated with the condition, and current clinical treatments remain inadequate. In this study, we focus on pyroptosis and engineered the camouflage protein (GSDMD‐C) attached to the ...
Yufei Liu, Jie Zhou, Yukang Wang, Zhihui Hu, Guimin Yin, Mengsen Zhu, Jianke Huo, Chenyang Zhang, Yiming Wang, Shuang Fu, Jinpeng Wan, Jie Wang, Lanju Xu, Zhiling Zhang, Shufang Wang   +14 more
wiley   +1 more source

A sustained NAD⁺ supplementation-biosynthesis nanoplatform for metabolic restoration in aged bone regeneration. [PDF]

Bioact Mater
Xie F, He Z, Xu S, Bai X, Wang X, Zhang F, Yuan Y, Liu C, Niu D.   +8 more
europepmc   +1 more source

Bone Marrow Stem Cell Exosomes Protect Lung Cells from Oxygen Damage by Regulating miR‐23a‐3p/Slc7a2 Pathway

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
Exosomal miR‐23a‐3p from BMSCs directly targets Slc7a2 mRNA. By repressing Slc7a2, miR‐23a‐3p suppresses hyperoxia‐triggered apoptosis, facilitates proliferation and reduces ROS production in AECIIs in vitro. The miR‐23a‐3p/Slc7a2 axis modulates numerous biochemical markers in AECII supernatant and neonatal rat serum under hyperoxia (P 〈 0.05 ...
Qifei He, Huaiwu Zheng, Junhao Xiong, Wei Yang   +3 more
wiley   +1 more source

Trabecular-Like Scaffold Dictates Osteogenesis via Fluid Shear Stress-Induced Metabolic Reprogramming through the CAV1-HIF-1α Axis. [PDF]

Research (Wash D C)
Gong W, Zhang J, Liu X, Zhou S, Huang K, Jin J, Gu J, Cui J, Li A, Liang H, Wang P, Jiang Q.   +11 more
europepmc   +1 more source

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu, Yi‐Fan Gu, Jian‐Qiao Li, Yi‐Heng Li, Yu‐Hu Chen, Lin‐Hui Wang, Zi‐Ru Wang, Yi‐Cong Wang, Min Yang   +8 more
wiley   +1 more source