We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen +10 more
wiley +1 more source
Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li +8 more
wiley +1 more source
Equine experimental lameness induction models
Summary Equine lameness due to musculoskeletal injury remains a common and significant cause of decreased performance. While our understanding and management of lameness have improved with advanced imaging, as well as diagnostic and therapeutic progression, a need for experimental equine models of lameness remains.
A. Dockery, B. Beasley, V. J. Moorman
wiley +1 more source
Identification and validation of lactate‐related genes biomarkers for steroid‐induced osteonecrosis of the femoral head through integrated bioinformatics analysis, machine learning, and experimental verification. ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle‐aged adults. However,
Zehua Wang +7 more
wiley +1 more source
CGRP-empowered stem cell sheet/short nanofiber sponge <i>via</i> enhancing neurovascular coupling for bone regeneration. [PDF]
Jia Y +10 more
europepmc +1 more source
Exercise rejuvenates bone marrow mesenchymal stem cells associated with the inhibition of inflammatory factors and senescence-related factors. [PDF]
Dong XJ +5 more
europepmc +1 more source
Differentiating Osteocytes from BMSCs in Collagen Gel
Roope Ohlsbom +4 more
openaire +1 more source
Dihydrocapsaicin Secreted by RYK Silenced Bone Marrow-Derived Mesenchymal Stem Cells Triggers Apoptosis of Gastric Cancer Cells. [PDF]
Fu Y, Cai Z, Wang Y, Huang M, Huang J.
europepmc +1 more source
hUMSCs-exo@Cyasterone protects the cell model of steroid-induced femur head necrosis by regulating N-glycosylation modification of CTSD-N258A. [PDF]
Sun Y +5 more
europepmc +1 more source
Synthesis of behavioral models from scenarios
Kramer, J, Magee, J, Uchitel, S
core +1 more source

