Results 221 to 230 of about 21,955 (252)

Manganese dioxide coupled metal-organic framework as mitophagy regulator alleviates periodontitis through SIRT1-FOXO3-BNIP3 signaling axis.

Biomaterials
Periodontitis is a prevalent chronic inflammatory disease characterized by alveolar bone resorption. Its progression is closely linked to oxidative stress where reactive oxygen species (ROS) generated by mitochondria exacerbate inflammation in positive ...
Cheng Zhu, Kai Huang, Tiancheng Li, Yixin Li, Yu Jin, Ruo-cheng Li, Zhiyu Zhu, Shengbing Yang, L. Xia, Bing Fang   +9 more
semanticscholar   +1 more source

Neutrophil extracellular traps aggravate placental injury in OAPS by facilitating activation of BNIP3 mediated mitophagy.

Free Radical Biology & Medicine
Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disease mediated by antiphospholipid antibodies (aPL), characterized by miscarriage, pre-mature birth caused by pre-eclampsia, intrauterine growth restriction, and other pregnancy complications.
Chunying Wang, Anna Li, Cancan Zhang, Zexin Yang, Xuan Yang, Weiyi Qi, Tengwei Liu, Meihua Zhang, Xietong Wang   +8 more
semanticscholar   +1 more source

Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming

Autophagy
Uveal melanoma (UM) is an aggressive intraocular malignancy derived from melanocytes in the uvea tract of the eye. Up to 50% of patients with UM develop distant metastases which is usually fatal within one year; preventing metastases is therefore ...
Jie Sun, Jie Ding, Han Yue, Binbin Xu, Akrit Sodhi, K. Xue, H. Ren, Jiang Qian   +7 more
semanticscholar   +1 more source

The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria

Journal of Cell Biology
The precise roles of the mitophagy receptors BNIP3 and NIX remain unclear. This study demonstrates that they are required for tight attachment and expansion of the isolation membrane along the mitochondrial surface, supporting a characteristic ...
S. Yamashita, R. Arai, H. Hada, B. Padman, M. Lazarou, David C. Chan, T. Kanki, S. Waguri   +7 more
semanticscholar   +1 more source

BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation

Autophagy
Adipose tissue macrophages (ATMs) are key cellular components that respond to nutritional excess, contributing to obesity-induced inflammation and insulin resistance.
Sangseob Kim, Cheoljun Choi, Yeonho Son, Junhyuck Lee, Sungug Joo, Yun-Hee Lee   +5 more
semanticscholar   +1 more source

BNIP3 induces apoptosis and protective autophagy under hypoxia in esophageal squamous cell carcinoma cell lines: BNIP3 regulates cell death

Diseases of the Esophagus, 2017
Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP3), a pro-apoptosis protein regulated by the methylation status of its promoter, has been implicated in inducing autophagy. However, the roles of BNIP3 and BNIP3-induced autophagy under hypoxia remain uncertain in esophageal squamous cell carcinoma (ESCC).
Z, Ma, C, Chen, P, Tang, H, Zhang, J, Yue, Z, Yu   +5 more
openaire   +2 more sources

Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury

International Journal on Biological Sciences
Mitophagy selectively eliminates damaged or dysfunctional mitochondria, playing a crucial role in maintaining mitochondrial quality control. However, it remains unclear whether mitophagy can be fully activated and how it evolves after SCI.
Hui Yao, Chaoyang Cai, Weijun Huang, Caizhen Zhong, Tianlun Zhao, Jiawei Di, Juliang Tang, Depeng Wu, Mao Pang, Lei He, L. Rong, Bin Liu   +11 more
semanticscholar   +1 more source

VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells

Angiogenesis, 2011
Hypoxia results in the apoptotic death of myocytes, neurons, and epithelial cells, through the actions of Bcl-2 and Nineteen kilodalton Interacting Protein-3 (BNIP3). On the contrary, endothelial cells are especially adept at surviving conditions of oxygen deprivation via up-regulation of vascular endothelial growth factor (VEGF) the most potent ...
Paul, Jurasz, Natasha, Yurkova, Lorrie, Kirshenbaum, Duncan J, Stewart   +3 more
openaire   +2 more sources

H-ras up-regulates expression of BNIP3.

Anticancer research, 2011
Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3) is a key regulator of cell death/autophagy and can act as an effector of a necrosis-like, atypical death program. It was implicated in execution of cell death induced by cluster of differentiation 47 (CD47).
Wojciech, Kalas, Ewelina, Swiderek, Andrzej, Rapak, Magdalena, Kopij, Janusz, Rak, Leon, Strzadala   +5 more
openaire   +2 more sources

GDF15 attenuates myocardial hypoxic injury by inhibiting mitochondrial damage through BNIP3 pathway

Molecular Biology Reports
Growth differentiation factor 15 (GDF15), a hypoxia-responsive mediator in myocardial injury, is established as a mitochondrial stress biomarker in skeletal muscle.
Jingjing Huang, Bo Pan, Zhichao He, Yuyu Liu, Changyao Wang, Junyao Tong, Jingyuan Shao, Xuan Tang, Peihong Hou, Xinhuan Ding, Hua Wang, Haiyan Zhu   +11 more
semanticscholar   +1 more source