Results 1 to 10 of about 3,099 (107)

IFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study [PDF]

Viruses, 2023
More than 40 human infections with the zoonotic Borna disease virus 1 (BoDV-1) have been reported to German health authorities from endemic regions in southern and eastern Germany.
Lisa Eidenschink, Gertrud Knoll, Dennis Tappe, Robert Offner, Thomas Drasch, Yvonne Ehrl, Bernhard Banas, Miriam C Banas, Hans Helmut Niller, André Gessner, Josef Köstler, Benedikt M J Lampl, Matthias Pregler, Melanie Völkl, Jürgen Kunkel, Bernhard Neumann, Klemens Angstwurm, Barbara Schmidt, Markus Bauswein   +18 more
doaj   +5 more sources

Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany [PDF]

Viruses, 2023
More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study (“BoDV-1 after solid ...
Markus Bauswein, Lisa Eidenschink, Gertrud Knoll, Bernhard Neumann, Klemens Angstwurm, Saida Zoubaa, Markus J Riemenschneider, Benedikt M J Lampl, Matthias Pregler, Hans Helmut Niller, Jonathan Jantsch, André Gessner, Yvonne Eberhardt, Gunnar Huppertz, Torsten Schramm, Stefanie Kühn, Michael Koller, Thomas Drasch, Yvonne Ehrl, Bernhard Banas, Robert Offner, Barbara Schmidt, Miriam C. Banas   +22 more
doaj   +5 more sources

Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany [PDF]

Emerging Microbes and Infections, 2022
In 2021, three encephalitis cases due to the Borna disease virus 1 (BoDV-1) were diagnosed in the north and east of Germany. The patients were from the states of Thuringia, Saxony-Anhalt, and Lower Saxony.
Christina Frank, Jonathan Wickel, Dirk Brämer, Jakob Matschke, Richard Ibe, Caroline Gazivoda, Albrecht Günther, Christian Hartmann, Kordt Rehn, Daniel Cadar, Thomas E. Mayer, Kirsten Pörtner, Hendrik Wilking, Jonas Schmidt-Chanasit, Dennis Tappe   +14 more
doaj   +4 more sources

Lethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography [PDF]

Nature Communications
Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon)
Arnt Ebinger, Pauline D. Santos, Florian Pfaff, Ralf Dürrwald, Jolanta Kolodziejek, Kore Schlottau, Viktoria Ruf, Friederike Liesche-Starnecker, Armin Ensser, Klaus Korn, Reiner Ulrich, Jenny Fürstenau, Kaspar Matiasek, Florian Hansmann, Torsten Seuberlich, Daniel Nobach, Matthias Müller, Antonie Neubauer-Juric, Marcel Suchowski, Markus Bauswein, Hans-Helmut Niller, Barbara Schmidt, Dennis Tappe, Daniel Cadar, Timo Homeier-Bachmann, Viola C. Haring, Kirsten Pörtner, Christina Frank, Lars Mundhenk, Bernd Hoffmann, Jochen Herms, Wolfgang Baumgärtner, Norbert Nowotny, Jürgen Schlegel, Rainer G. Ulrich, Martin Beer, Dennis Rubbenstroth   +36 more
doaj   +8 more sources

Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection [PDF]

Emerging Microbes and Infections
Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and ...
Yannik Vollmuth, Nicola Jungbäck, Tatiana Mögele, Friederike Schmidt-Graf, Silke Wunderlich, Mareike Schimmel, Camilla Rothe, Leonhard Stark, Jürgen Schlegel, Georg Rieder, Thomas Richter, Tina Schaller, Dennis Tappe, Bruno Märkl, Kaspar Matiasek, Friederike Liesche-Starnecker   +15 more
doaj   +5 more sources

Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective. [PDF]

PLoS Pathogens
Human Borna disease virus 1 (BoDV-1) encephalitis is characterized by rapid clinical progression, an absence of a causal therapy and an extremely high case fatality rate.
Kirsten Pörtner, Christina Frank, Hendrik Wilking, Klaus Stark, Christiane Herden, Martin Beer, Dennis Rubbenstroth, Dennis Tappe   +7 more
doaj   +6 more sources

Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cells [PDF]

npj Viruses
Mammalian orthobornaviruses, such as Borna disease virus 1 (BoDV-1) and variegated squirrel bornavirus 1, are zoonotic pathogens that cause fatal encephalitis in humans.
Takehiro Kanda, Pauline Dianne Santos, Dirk Höper, Martin Beer, Dennis Rubbenstroth, Keizo Tomonaga   +5 more
doaj   +4 more sources

Case report: Fatal Borna virus encephalitis manifesting with basal brain and brainstem symptoms [PDF]

Frontiers in Neurology, 2023
BackgroundSince the first report of fatal Borna virus-1 (BoDV-1) encephalitis in 2018, cases gradually increased. There is a lack of diagnostic algorithm, and there is no effective treatment so far.Case presentationWe report an acute BoDV-1 encephalitis ...
Athanasios Lourbopoulos, Athanasios Lourbopoulos, Lea Schnurbus, Ricarda Guenther, Susanne Steinlein, Viktoria Ruf, Jochen Herms, Klaus Jahn, Klaus Jahn, Volker Huge, Volker Huge   +10 more
doaj   +5 more sources

The structure of the mammalian bornavirus polymerase complex [PDF]

Nature Communications
Borna disease virus 1 (BoDV-1) is a non-segmented RNA virus with one of the smallest known RNA virus genomes. BoDV-1 replicates in the nucleus of infected cells using a virally encoded polymerase complex composed of the large protein and phosphoprotein ...
Loïc Carrique, Franziska Günl, Adrian Deng, Jonathan M. Grimes, Jeremy R. Keown   +4 more
doaj   +4 more sources

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis [PDF]

Pediatric Reports, 2023
Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (
Matteo Riccò, Ilaria Zanella, Elia Satta, Silvia Ranzieri, Silvia Corrado, Federico Marchesi, Simona Peruzzi   +6 more
doaj   +2 more sources