Case Reports in Psychiatry, 2023 Objective. Borna disease virus 1 (BoDV-1) was proven to cause fatal encephalitis in humans in 2018. However, the effects of persistent infections remain unclear.
Hidenori Matsunaga +9 more
doaj +2 more sources
Long-Term Survival of Borna Disease Virus 1 (BoDV-1)-Encephalitis: An Exceptional Case with Valuable Insights for Pathophysiology and Disease Management [PDF]
Infectious Diseases and TherapyIntroduction Borna disease virus 1 (BoDV-1) encephalitis has a (sub)acute and mostly fatal course. Initial flu-like symptoms are typically followed by rapid progressive panencephalitis and death within weeks. No curative therapy exists so far. We present
Denis Grabova +19 more
doaj +2 more sources
Clinical Features of BoDV-1 Encephalitis: A Systematic Review
Zoonotic Diseases, 2023 Human cases of fatal encephalitis caused by Borna disease virus 1 (BoDV-1) have been increasingly reported. We envisaged the present systematic review in order to provide a comprehensive summary of clinical features associated with BoDV-1 encephalitis ...
Matteo Riccò +2 more
exaly +3 more sources
BoDV-1 Infection Is Associated with Altered Prion Protein Glycoform Maturation and Reduced ETS1-MGAT5/GnTV Pathway Activity in Rat C6 Astroglial Cells [PDF]
MicroorganismsBorna disease virus 1 (BoDV-1) is a noncytolytic, neurotrophic virus that causes neurological disorders, where astrocytes contribute to neuropathology. Cellular prion protein (PrPC) is involved in pro-survival signaling and antioxidative defense.
Akikazu Sakudo, Kazuyoshi Ikuta
doaj +2 more sources
Borna Disease Virus 1 as Cause of Fatal Meningoencephalomyelitis in Wild Hedgehogs, Germany, 2022–2025 [PDF]
Emerging Infectious DiseasesBorna disease virus 1 (BoDV-1) causes encephalitis with a fatality rate of >90% in domestic mammals and humans. Currently, the bicolored white-toothed shrew is the only known reservoir host. We report BoDV-1 infections in 15 wild European hedgehogs from
Effrosyni Michelakaki +15 more
doaj +2 more sources
Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective. [PDF]
PLoS PathogensHuman Borna disease virus 1 (BoDV-1) encephalitis is characterized by rapid clinical progression, an absence of a causal therapy and an extremely high case fatality rate.
Kirsten Pörtner +7 more
doaj +3 more sources
Multimodal profiling of immune responses reveals innate-adaptive immune imbalance in human bornavirus encephalitis [PDF]
Acta Neuropathologica CommunicationsHuman bornavirus encephalitis (BVE) is a rare, emerging and fatal zoonotic disease mainly caused by the Borna disease virus 1 (BoDV-1), a non-cytolytic RNA virus.
Nicola Jungbäck +14 more
doaj +2 more sources
Mapping Bornavirus encephalitis-A comparative study of viral spread and immune response in human and animal dead-end hosts. [PDF]
PLoS PathogensBorna disease virus 1 (BoDV-1) has long been recognized as a cause of fatal encephalitis in animals and was only recently identified as a zoonotic pathogen causing a similar disease in humans.
Yannik Vollmuth +10 more
doaj +2 more sources
Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cells [PDF]
npj VirusesMammalian orthobornaviruses, such as Borna disease virus 1 (BoDV-1) and variegated squirrel bornavirus 1, are zoonotic pathogens that cause fatal encephalitis in humans.
Takehiro Kanda +5 more
doaj +2 more sources
Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses [PDF]
npj VirusesVariegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain.
Akiko Makino +3 more
doaj +2 more sources