Results 31 to 40 of about 3,069 (98)

Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany [PDF]

Scientific Reports, 2019
Christina Frank, Martin Beer, Dennis Rubbenstroth   +2 more
exaly   +2 more sources

Distinct 5' UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses. [PDF]

Microbiol Immunol
ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Wu MC, Kanda T, Komorizono R, Sakai M, Leacy A, Susta L, Makino A, Tomonaga K.   +7 more
europepmc   +2 more sources

Structural and biophysical characterization of the Borna disease virus 1 phosphoprotein

Acta Crystallographica Section F, Volume 79, Issue 3, Page 51-60, March 2023., 2023
The phosphoprotein is an essential component of the replication complex in bornaviruses. Here, using X‐ray crystallography, the structure of the phosphoprotein from Borna disease virus 1 is presented and its flexibility in solution is characterized.Bornaviruses are RNA viruses with a mammalian, reptilian, and avian host range.
Jack D. Whitehead, Jonathan M. Grimes, Jeremy R. Keown   +2 more
wiley   +1 more source

New World camelids are sentinels for the presence of Borna disease virus

Transboundary and Emerging Diseases, Volume 69, Issue 2, Page 451-464, March 2022., 2022
Abstract Borna disease (BD), a frequently fatal neurologic disorder caused by Borna disease virus 1 (BoDV‐1), has been observed for decades in horses, sheep, and other mammals in certain regions of Europe. The bicoloured white‐toothed shrew (Crocidura leucodon) was identified as a persistently infected species involved in virus transmission.
Alexandra J. Malbon, Ralf Dürrwald, Jolanta Kolodziejek, Norbert Nowotny, Ralph Kobera, Dietrich Pöhle, Aemero Muluneh, Eva Dervas, Christopher Cebra, Frank Steffen, Giulia Paternoster, Christian Gerspach, Monika Hilbe   +12 more
wiley   +1 more source

The Effect of miR‐505‐5p on Inhibition of Serum Uromodulin Ameliorates Myocardial Inflammation and Apoptosis Induced by Ischemia‐Reperfusion

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Background. It has been found that miR‐505‐5p is closely related to cardiovascular metabolic risk factors. Nonetheless, there is little research analyzing miR‐505‐5p for its role as well as molecular mechanism in myocardial injury caused by ischemia‐reperfusion (I/R). Methods.
Dongsheng He, Jun Hu, Yuhai Lu, Weikun Jia, Minxue Wei, Xiaofei Zeng, Hong Wang, Shao Liang   +7 more
wiley   +1 more source

A Small Interfering RNA Cocktail Targeting the Nucleoprotein and Large Protein Genes Suppresses Borna Disease Virus Infection

Frontiers in Microbiology, 2019
Recently, Borna disease virus (BoDV-1)-related fatal encephalitis human cases have been reported, which highlights the potential of BoDV-1 to cause fatal human diseases.
Da Teng, Shunsuke Obika, Keiji Ueda, Tomoyuki Honda   +3 more
doaj   +1 more source

Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1

Viruses, 2022
Borna disease virus 1 (BoDV-1) is a neurotropic RNA virus belonging to the family Bornaviridae within the order Mononegavirales. Whereas BoDV-1 causes neurological and behavioral disorders, called Borna disease (BD), in a wide range of mammals, its ...
Takehiro Kanda, Keizo Tomonaga
doaj   +1 more source

Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Borna disease virus 1 (BoDV-1) infection induces cognitive impairment in rodents. Emerging evidence has demonstrated that Chromatin remodeling through histone acetylation can regulate cognitive function.
Jie Jie, Xiaoyan Xu, Jinjun Xia, Zhe Tu, Yujie Guo, Chenmeng Li, Xiong Zhang, Haiyang Wang, Weihong  Song, Peng Xie   +9 more
doaj   +1 more source

Word recognition memory and serum levels of Borna disease virus specific circulating immune complexes in obsessive–compulsive disorder

BMC Psychiatry, 2022
Background Borna disease virus 1 (BoDV-1) is a non-segmented, negative-strand RNA virus that persistently infects mammals including humans. BoDV-1 worldwide occurring strains display highly conserved genomes with overlapping genetic signatures between ...
Yuanyuan Zhang, A Alwin Prem Anand, Liv Bode, Hanns Ludwig, Hinderk M. Emrich, Detlef E. Dietrich   +5 more
doaj   +1 more source

Human Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease

Emerging Microbes and Infections, 2022
Human Borna disease virus 1 (BoDV-1) encephalitis is a severe emerging disease with a very high case-fatality rate. While the clinical disease, case definitions, diagnostic algorithms and neuropathology have been described, very little is known about the
Jessica Rauch, Johanna Friederike Steffen, Birgit Muntau, Jana Gisbrecht, Kirsten Pörtner, Christiane Herden, Hans Helmut Niller, Markus Bauswein, Dennis Rubbenstroth, Ute Mehlhoop, Petra Allartz, Dennis Tappe   +11 more
doaj   +1 more source