Results 31 to 40 of about 3,162 (145)

Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species [PDF]

Frontiers in Veterinary Science
Although laboratory methods have advanced, the cause of many encephalitides is still unknown. Molecular methods like multiplex PCR and microarrays are considered to be often less sensitive than Next Generation Sequencing, whereas the latter is time ...
Madeleine de le Roi, Hannah Gerhards, Adnan Fayyad, Adnan Fayyad, Mathias Boelke, Stefanie Christine Becker, Asisa Volz, Ingo Gerhauser, Wolfgang Baumgärtner, Christina Puff   +9 more
doaj   +2 more sources

Long-term Elevation of Complement Factors in Cerebrospinal Fluid of Patients With Borna Disease Virus 1 Encephalitis. [PDF]

J Infect Dis
Background Borna disease virus 1 (BoDV-1) causes rare but severe zoonotic infections in humans, presenting as encephalitis. The case-fatality risk is very high and no effective countermeasures have been established so far.
Bauswein M, Zoubaa S, Toelge M, Eidenschink L, Riemenschneider MJ, Neumann B, Lee DH, Eid E, Tappe D, Niller HH, Gessner A, Schmidt B, Bülow S, Angstwurm K.   +13 more
europepmc   +3 more sources

First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications. [PDF]

Infection, 2023
AbstractBackgroundThe Borna disease virus (BoDV-1) is an emerging zoonotic virus causing severe and mostly fatal encephalitis in humans.Methods and ResultsA local cluster of fatal BoDV-1 encephalitis cases was detected in the same village three years apart affecting two children.
Grosse L, Lieftüchter V, Vollmuth Y, Hoffmann F, Olivieri M, Reiter K, Tacke M, Heinen F, Borggraefe I, Osterman A, Forstner M, Hübner J, von Both U, Birzele L, Rohlfs M, Schomburg A, Böhmer MM, Ruf V, Cadar D, Muntau B, Pörtner K, Tappe D.   +21 more
europepmc   +3 more sources

Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1 (BoDV-1) distributed in cattle in Hokkaido. [PDF]

J Vet Med Sci, 2021
Borna disease virus (BoDV) is a neurotropic virus that causes several infections in humans and neurological diseases in a wide range of animals worldwide. BoDV-1 has been molecularly and serologically detected in many domestic and wild animals in Japan; however, the genetic diversity of this virus and the origin of its infection are not fully ...
Sukmak M, Okamoto M, Ando T, Hagiwara K.
europepmc   +4 more sources

Intranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity. [PDF]

Int J Mol Sci, 2019
Mammalian Bornavirus (BoDV-1) typically causes a fatal neurologic disorder in horses and sheep, and was recently shown to cause fatal encephalitis in humans with and without transplant reception. It has been suggested that BoDV-1 enters the central nervous system (CNS) via the olfactory pathway.
Kupke A, Becker S, Wewetzer K, Ahlemeyer B, Eickmann M, Herden C.   +5 more
europepmc   +4 more sources

The Borna Disease Virus 2 (BoDV-2) Nucleoprotein Is a Conspecific Protein That Enhances BoDV-1 RNA-Dependent RNA Polymerase Activity. [PDF]

J Virol, 2021
Borna disease virus 1 (BoDV-1), a prototype virus of the species Mammalian 1 orthobornavirus , is a nonsegmented negative-strand RNA virus that persists in the host nucleus. The nucleoprotein (N) of BoDV-1 encapsidates genomic and antigenomic viral RNA, playing important roles in viral transcription and replication.
Kanda T, Horie M, Komatsu Y, Tomonaga K.
europepmc   +3 more sources

Distinct 5' UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses. [PDF]

Microbiol Immunol
ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Wu MC, Kanda T, Komorizono R, Sakai M, Leacy A, Susta L, Makino A, Tomonaga K.   +7 more
europepmc   +2 more sources

Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment

Viruses, 2023
Borna disease virus (BoDV-1) is a highly neurotropic RNA virus that causes neurobehavioral disturbances such as abnormal social activities and memory impairment.
Da Teng, Keiji Ueda, Tomoyuki Honda
doaj   +1 more source

Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis. [PDF]

Infection
Abstract Background Within endemic regions in southern and eastern Germany, Borna disease virus 1 (BoDV-1) causes rare zoonotic spill-over infections in humans, leading to encephalitis with a high case-fatality risk.
Bauswein M, Eid E, Eidenschink L, Schmidt B, Gessner A, Tappe D, Cadar D, Böhmer MM, Jockel L, van Wickeren N, Garibashvili T, Wiesinger I, Wendl C, Heckmann JG, Angstwurm K, Freyer M.   +15 more
europepmc   +5 more sources

Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections [PDF]

, 2022
Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal BoDV-1 infection diagnosed on day 12 after hospitalization by ...
Angstwurm, Klemens, Asbach, Benedikt, Bauswein, Markus, Beer, Martin, Böhmer, Merle M., Eidenschink, Lisa, Evert, Katja, Gessner, André, Knoll, Gertrud, Lampl, Benedikt M.J., Linker, Ralf A., Neumann, Bernhard, Niller, Hans Helmut, Pregler, Matthias, Riemenschneider, Markus J., Rubbenstroth, Dennis, Scheiter, Alexander, Schlottau, Kore, Schmidt, Barbara, Schreiner, Patrick, Soutschek, Erwin, Zoubaa, Saida   +21 more
core   +1 more source