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Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering [PDF]
Sensors, 2015 Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate ...
Ana Rubina Perestrelo +3 more
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Latest Trends in Biosensing for Microphysiological Organs-on-a-Chip and Body-on-a-Chip Systems
Biosensors, 2019 Organs-on-chips are considered next generation in vitro tools capable of recreating in vivo like, physiological-relevant microenvironments needed to cultivate 3D tissue-engineered constructs (e.g., hydrogel-based organoids and spheroids) as well as ...
Sebastian Rudi Adam Kratz +4 more
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Micromachines, 2021 Organ-on-a-chip technology has the potential to accelerate pharmaceutical drug development, improve the clinical translation of basic research, and provide personalized intervention strategies.
Mario Rothbauer +6 more
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Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
Micromachines, 2021 Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies.
Leslie Donoghue +3 more
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Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)
Frontiers in Cell and Developmental Biology, 2021 Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases.
Mridu Malik +6 more
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Pharmaceutics, 2022 Stem cell technology and embryonic stem cell models are of great interest in biomedical research since they provide deeper insights into, e.g., neurogenesis and early mammalian brain development.
Christoph Eilenberger +6 more
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Towards establishing human body-on-a-chip systems
Stem Cell Research & Therapy, 2022 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically ...
Zhong Alan Li, Rocky S. Tuan
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Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine
Bioactive Materials, 2021 Nanomedicine involves the use of engineered nanoscale materials in an extensive range of diagnostic and therapeutic applications and can be applied to the treatment of many diseases.
Xi Chen +3 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of atherosclerotic cardiovascular disease, cancer, and mortality. The relationship between a healthy lifestyle and CHIP is unknown. Methods and
Bernhard Haring +18 more
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Journey of organ on a chip technology and its role in future healthcare scenario
Applied Surface Science Advances, 2022 Organ on a chip refers to microengineered biomimetic system which reflects structural and functional characteristics of human tissue. It involves biomaterial technology, cell biology and engineering combined together in a miniaturized platform.
Deepanmol Singh +4 more
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