Results 21 to 30 of about 718 (167)
A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
Micromachines, 2021 Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye +5 more
doaj +1 more source
Research on an Off-Chip Microvalve for Pneumatic Control in Microfluidic Chips
Energies, 2022 A compact, rapid, and portable off-chip pneumatic control valve is significant for the miniaturization and integration of external pneumatic systems for microfluidic chips.
Xuling Liu +7 more
doaj +1 more source
Microtechnology-Based Multi-Organ Models
Bioengineering, 2017 Drugs affect the human body through absorption, distribution, metabolism, and elimination (ADME) processes. Due to their importance, the ADME processes need to be studied to determine the efficacy and side effects of drugs. Various in vitro model systems
Seung Hwan Lee, Jong Hwan Sung
doaj +1 more source
Physiological and Disease Models of Respiratory System Based on Organ-on-a-Chip Technology
Micromachines, 2021 The pathogenesis of respiratory diseases is complex, and its occurrence and development also involve a series of pathological processes. The present research methods are have difficulty simulating the natural developing state of the disease in the body ...
Di Wang +7 more
doaj +1 more source
Design and research of a conveying device for metal parts processing [PDF]
MATEC Web of Conferences, 2022 The utility model relates to a conveying device for processing metal accessories with vibration type chip removal, which comprises an outer frame body, a conveying roller, a support plate, a conveying belt and a sprocket mechanism.
Wan Zhiqiang +2 more
doaj +1 more source
Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro
Advanced Science, 2019 The integration of metabolic competence in developmental toxicity assays in vitro is of fundamental importance to better predict adverse drug effects.
Julia Alicia Boos +4 more
doaj +1 more source
4.5kV FRD Development for high current power modules
MATEC Web of Conferences, 2018 A 4.5kV/100A FRD was designed by simulation, which had optimized carrier density distribute cell and ruggedness terminal. The cell was composed of P-body/N-sub/N+ layers, when the P-body doping concentration is lower, the carrier density distribution on ...
Liu Jiang +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source