Microfabrication of Embedding a Flexible Parylene-Based Microelectrode Array within Body-on-a-Chip
Proceedings, 2017 To study drug response on human heart cells and predict drug induced cardiotoxicity, a microfluidic cell culture device with an integrated microelectrode array (MEA) is a promising approach.
Tatsuya Omaki +4 more
doaj +1 more source
Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism [PDF]
, 2014 Intelligent in vitro models able to recapitulate the physiological interactions between tissues in the body have enormous potential as they enable detailed studies on specific two-way or higher order tissue communication.
Arti Ahluwalia +2 more
core +2 more sources
Towards Multi-Organoid Systems for Drug Screening Applications
Bioengineering, 2018 A low percentage of novel drug candidates succeed and reach the end of the drug discovery pipeline, mainly due to poor initial screening and assessment of the effects of the drug and its metabolites over various tissues in the human body.
Cláudia C. Miranda +3 more
doaj +1 more source
Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
doaj +1 more source
Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. [PDF]
, 2016 Transient propagation of information across neuronal assembles is thought to underlie many cognitive processes. However, the nature of the neural code that is embedded within these transmissions remains uncertain.
Alagapan, Sankaraleengam +4 more
core +1 more source
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders [PDF]
, 2022 The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs.
Albani D. +4 more
core +4 more sources
Automatic Detection of Chip Pin Defect in Semiconductor Assembly Using Vision Measurement
Measurement Science Review, 2022 With the development of semiconductor assembly technology, the continuous requirement for the improvement of chip quality caused an increasing pressure on the assembly manufacturing process.
Lu Shengfang +3 more
doaj +1 more source
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]
, 2017 Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li +5 more
core +2 more sources
A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
Micromachines, 2021 Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses.
Yasmin Roye +5 more
doaj +1 more source
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]
, 2015 Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Bauer, Sophie +13 more
core +1 more source