Results 41 to 50 of about 133,256 (260)

4.5kV FRD Development for high current power modules

MATEC Web of Conferences, 2018
A 4.5kV/100A FRD was designed by simulation, which had optimized carrier density distribute cell and ruggedness terminal. The cell was composed of P-body/N-sub/N+ layers, when the P-body doping concentration is lower, the carrier density distribution on ...
Liu Jiang, Liu Yueyang, Jin Rui, He Feng, Dong Shaohua, Pan Yan, Wu Junmin   +6 more
doaj   +1 more source

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development [PDF]

, 2014
Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations.
Borenstein, Jeffrey T., Ebrahimkhani, Mohammad Reza, Griffith, Linda G., Lauffenburger, Douglas A., Young, Carissa L.   +4 more
core   +1 more source

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. [PDF]

, 2014
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of
Alépée, N., Bahinski, A., Daneshian, M., De Wever, B., Fritsche, E., Goldberg, A., Hansmann, J., Hartung, T., Haycock, J., Hoelting, L., Hogberg, H., Kadereit, S., Kelm, J.M., Landsiedel, R., Leist, M., Lübberstedt, M., McVey, E., Noor, F., Pellevoisin, C., Petersohn, D., Pfannenbecker, U., Ramirez, T., Reisinger, K., Rothen-Rutishauser, B., Schäfer-Korting, M., Zeilinger, K., Zurich, M.G.   +26 more
core   +3 more sources

Organ-on-a-Chip systems for new drugs development [PDF]

, 2021
Research on alternatives to the use of animal models and cell cultures has led to the creation of organ-on-a-chip systems, in which organs and their physiological reactions to the presence of external stimuli are simulated.
Andrea Egurbide-Sifre, Laura Medina, Ronny Vargas   +2 more
core   +2 more sources

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Integrating biological vasculature into a multi-organ-chip microsystem [PDF]

, 2013
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Brincker, Sven, Busek, Mathias, Groth, Benjamin, Hoffmann, Silke, Horland, Reyk, Lauster, Roland, Lindner, Gerd, Lorenz, Alexandra, Marx, Uwe, Menzel, Ulrike, Schimek, Katharina, Sonntag, Frank, Walles, Heike   +12 more
core   +2 more sources

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Development of Real-Time Transendothelial Electrical Resistance Monitoring for an In Vitro Blood-Brain Barrier System

Micromachines, 2020
Three-dimensional (3D) cell cultures and organs-on-a-chip have been developed to construct microenvironments that resemble the environment within the human body and to provide a platform that enables clear observation and accurate assessments of cell ...
Kai-Hong Tu, Ling-Shan Yu, Zong-Han Sie, Han-Yi Hsu, Khuloud T. Al-Jamal, Julie Tzu-Wen Wang, Ya-Yu Chiang   +6 more
doaj   +1 more source

A One-Dollar, Disposable, Paper-Based Microfluidic Chip for Real-Time Monitoring of Sweat Rate

Micromachines, 2022
Collecting sweat and monitoring its rate is important for determining body condition and further sweat analyses, as this provides vital information about physiologic status and fitness level and could become an alternative to invasive blood tests in the ...
Hongcheng Wang, Kai Xu, Haihao Xu, Along Huang, Zecong Fang, Yifan Zhang, Ze’en Wang, Kai Lu, Fei Wan, Zihao Bai, Qiao Wang, Linan Zhang, Liqun Wu   +12 more
doaj   +1 more source

Microfluidics : the fur-free way towards personalised medicine in cancer therapy [PDF]

, 2016
Microfluidic technology has great potential for complementing and, in some instances, replacing the use of animal models in the testing of medicines and in developing personalised treatments for cancer patients.
Bower, Ruth, Dawson, Amy, Green, Vicky, Greenman, John   +3 more
core