Results 61 to 70 of about 133,256 (260)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery

Current Research in Toxicology
Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths.
Aakash Patel, Suruchi Poddar, Daniel Nierenberg, Stephanie Lang, Hao Wang, Camilly Pestana Pires DeMello, Julio Gamarra, Alisha Colon, Paula Kennedy, Jeffry Roles, Jules Klion, Will Bogen, Christopher Long, Xiufang Guo, Patrick Tighe, Stephan Schmidt, Michael L. Shuler, James J. Hickman   +17 more
doaj   +1 more source

Recapitulating the tumor ecosystem along the metastatic cascade using 3D culture models [PDF]

, 2015
Advances in cancer research have shown that a tumor can be likened to a foreign species that disrupts delicately balanced ecological interactions, compromising the survival of normal tissue ecosystems.
Ackerman, Agus, Alexander, Anastasov, Anderson, Ashley, Attolini, Balaban, Barkan, Barkan, Barker, Basanta, Beck, Ben Sahra, Ben-Jacob, Benton, Bergers, Bersini, Bhatia, Bild, Bipat, Bissell, Blehm, Blehm, Box, Bozic, Bragado, Braun, Brown, Byun, Cahalan, Cahill, Cairns, Capparelli, Carrion, Chaffer, Chambers, Chen, Chen, Chiche, Chung, Chung, Chung, Chung, Cimetta, Colozza, Condeelis, Condeelis, Coussens, Cukierman, Cunningham, De Palma, de Visser, DeCosse, DelNero, DelNero, Derda, Derda, Ding, Dirat, Dolberg, Dudley, Dunne, Dvorak, Ebrahimkhani, Egeblad, Esch, Even-Ram, Findlay, Fischbach, Fisher, Franco, Frantz, Frese, Frieboes, Frieboes, Friedl, Gabrilovich, Gajewski, Gardel, Garraway, Gerlinger, Germain, Ghaemmaghami, Ghajar, Gordon, Grivennikov, Gupta, Haessler, Han, Hanahan, Harisinghani, Harris, Hasebe, Helmchen, Helmlinger, Hennessy, Hirschhaeuser, Hoffman, Hoffmann, Horch, Huh, Huh, Husemann, Hwang, Ilan, Infanger, Ingber, Ingber, Ingram, Jeon, Jeong, Jeong, Jimenez-Andrade, Jones, Judenhofer, Junttila, Kallinowski, Kalluri, Kang, Katz, Kenny, Kern, Kessenbrock, Keung, Khacho, Khademhosseini, Khazaie, Kim, Kim, Kim, Kim, Kleinman, Korolev, Koukourakis, Krause, Kross, Kumar, Lancaster, Lee, Lee, Legant, Levental, Levental, Li, Li, Liebig, Lindau, Liotta, Liu, Lotze, Lovitt, Lu, Lutolf, Lynch, Ma, Maffini, Malanchi, Mancino, Mantovani, Mao, Martins-Green, Marushima, Marusyk, McGranahan, Meacham, Menendez, Michor, Mierke, Miller, Mintz, Moraes, Moreno-Bueno, Mouw, Mullighan, Murdoch, Na, Nasser, Netti, Nikkhah, Nomura, Nowell, Nyga, Odling-Smee, Odum, Ohlund, Onder, Ostman, O’Brien, O’Brien, Paget, Palucka, Pantel, Park, Pickup, Pickup, Pienta, Plodinec, Provenzano, Provenzano, Qian, Quail, Radisky, Radisky, Raeber, Restifo, Reya, Reya, Rizvi, Robey, Roussos, Roy, Rueckel, Sakaguchi, Sakaue-Sawano, Sato, Scheffer, Schewe, Schwartz, Scott, Serres, Shin, Shin, Shin, Slater, Sosa, Sounni, Sprouffske, Sudo, Swaminathan, Swanton, Swartz, Tan, Tanner, Tanner, Tanner, Thomas, Tlsty, Ulrich, Valastyan, van der Meer, van Nes, Vaupel, Vega-Naredo, Vermeulen, Villanueva, Vivier, von Boehmer, Wagle, Wagner, Weaver, Wellings, Wilson, Wojtkowiak, Wong, Wyckoff, Xu, Yamada, Yang, Yang, Young, Yu, Zerbini, Zervantonakis, Zhang, Zhao   +265 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Microdevice Platform for In Vitro Nervous System and Its Disease Model

Bioengineering, 2017
The development of precise microdevices can be applied to the reconstruction of in vitro human microenvironmental systems with biomimetic physiological conditions that have highly tunable spatial and temporal features.
Jin-Ha Choi, Hyeon-Yeol Cho, Jeong-Woo Choi   +2 more
doaj   +1 more source

Microfabricated Physiological Models for In Vitro Drug Screening Applications [PDF]

, 2016
Microfluidics and microfabrication have recently been established as promising tools for developing a new generation of in vitro cell culture microdevices.
Cruz Moreira, Catia Daniela, Rasponi, Marco, Redaelli, Alberto Cesare Luigi, Ugolini, Giovanni Stefano, Visone, Roberta   +4 more
core   +2 more sources

Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives. [PDF]

, 2021
Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug ...
Bhusal, Anant, Buyukoz, Melda, Cecen, Berivan, Dogan, Elvan, Karavasili, Christina, Kozaci, Leyla Didem, Miri, Amir K, Nazir, Mubashir, Shahriyari, Fatemeh, Tamburaci, Sedef   +9 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Industrial lab-on-a-chip: Design applications and scale-up for drug discovery and delivery [PDF]

, 2013
journal ...
ICHIKAWA Sosaku, Khalid Nauman, Kobayashi Isao, Kuroiwa Takashi, MARCOS ANTONIO DAS Neves, NAKAJIMA Mitsutoshi, Uemura Kunihiko, Vladisavljević Goran T.   +7 more
core   +1 more source