Results 71 to 80 of about 133,256 (260)

In vitro nonalcoholic fatty liver disease model with cyclo-olefin-polymer-based microphysiological systems [PDF]

, 2021
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver conditions, and its treatment involves curing the patients without liver transplantation.
Kamei, Ken-ichiro, Terada, Shiho, Wen, Xiaopeng, Yamanaka, Makoto, Yoshimoto, Koki   +4 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

DESIGN AND DEVELOPMENT OF A MICROFLUIDIC DEVICE FOR THE ASSESSMENT OF FIRST-PASS METABOLISM [PDF]

, 2017
The aim of the thesis is to develop a microfluidic platform in order to mimic the first pass metabolism of oral ingested compounds. In the first part of the thesis, there is an introduction about the in vivo mechanism involved in the in process of first ...
Corrado, Brunella
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Design of An Intelligent Split-type Electricity Utilization Measurement and Control Terminal for Local Household Energy Management and Optimization

E3S Web of Conferences, 2018
It is of great significance to implement automatic demand response (ADR) in the energy Internet based on accurate measurement and control of electricity utilization devices using intelligent terminals.
Xie Baiming, Cheng Lefeng, Ding Chao, Shi Shouyuan, Tan Zhukui, Li Zhengjia, Liu Bin, Hua Jinxiu, Huang Wenjing   +8 more
doaj   +1 more source

A Microfluidic Device for Culturing an Encapsulated Ovarian Follicle

Micromachines, 2017
Microfluidic chips have been proved effective in mimicking different organs of human body. Simulating human ovarian follicles by microfluidic device will be useful in exploring the mechanism of folliculogenesis and related diseases.
Aziz Ur Rehman Aziz, Mengjie Fu, Jiu Deng, Chunyang Geng, Yong Luo, Bingcheng Lin, Xiaohui Yu, Bo Liu   +7 more
doaj   +1 more source

Characterization of Dielectrophoresis Based Relay-Assisted Molecular Communication Using Analogue Transmission Line

IEEE Access, 2020
Increase in research focus on developing lab-on-chip based devices like Body-on-chip and Organ-on-chip, have led to a higher number of functional entities in lab-on-chip. This, in turn, has led to increasingly complex microfluidic channel networks. Thus,
Puneet Manocha, Gitanjali Chandwani, Soumen Das   +2 more
doaj   +1 more source

Emerging applications of nanotechnology for diagnosis and therapy of disease: a review [PDF]

, 2017
Nanotechnology is of increasing interest in the fields of medicine and physiology over recent years. Its application could considerably improve disease detection and therapy, and although the potential is considerable, there are still many challenges ...
Brivio D, Cheng X, Curley S A, Feng X, Hainfeld J F, Han D, Ivan Roitt, Liu J, Petrushev B, Poon W, Richard Bayford, Scarlet Xiaoyan Wang, Tom Rademacher, Urban C, Xu L, Zhang X-Y   +15 more
core   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source